SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Collection and Processing
2.2. Analysis of Differentially Expressed Genes (DEGs)
2.3. KEGG Pathway and GO Function Enrichment Analysis
2.4. Protein–Protein Interaction Analysis of DEGs and Hub Genes Screening
2.5. Survival Analysis of Hub Genes
2.6. Single Sample Gene Set Enrichment Analysis (ssGSEA)
2.7. Tissue Preparation
2.8. Immunohistochemistry
2.9. Statistical Analysis
3. Results
3.1. Analysis of DEGs
3.2. KEGG and GO Analysis of DEGs
3.3. PPI Network Construction and Screening for Hub Genes
3.4. Survival Analysis of Hub Genes
3.5. SsGSEA Results
3.6. Expression of SOCS1 in Different HNSCC Tissues and Patient Survival
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Symbol | Official Full Name | p Value | log FC | Type |
---|---|---|---|---|
EREG | Epiregulin | 0.656079718 | 0.371934432 | up |
PLCG1 | Phospholipase C Gamma 1 | 0.073832163 | 0.198323663 | up |
ERBB4 | Erb-B2 Receptor Tyrosine Kinase 4 | 0.029904345 | −0.902305788 | down |
HBEGF | Heparin Binding EGF Like Growth Factor | 0.215752146 | −0.390014359 | down |
ZFP42 | ZFP42 Zinc Finger Protein | 0.727807289 | 0.217809524 | up |
CBX6 | Chromobox 6 | 0.003652311 | −0.840880952 | down |
NFKBIA | NFKB Inhibitor Alpha | 0.453595663 | 0.143335238 | up |
SOCS1 | Suppressor Of Cytokine Signaling 1 | 0.007229292 | 0.675522051 | up |
ATP2B2 | ATPase Plasma Membrane Ca2+ Transporting 2 | 0.049796706 | −1.009179634 | down |
CEND1 | Cell Cycle Exit And Neuronal Differentiation 1 | 0.035879997 | −0.613561026 | down |
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Guo, M.; Zhang, L.; Wang, H.; Zhou, Q.; Zhu, X.; Fu, X.; Yang, J.; Liu, S.; Guo, D.; Zhang, B. SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas. Curr. Issues Mol. Biol. 2023, 45, 5598-5612. https://doi.org/10.3390/cimb45070353
Guo M, Zhang L, Wang H, Zhou Q, Zhu X, Fu X, Yang J, Liu S, Guo D, Zhang B. SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas. Current Issues in Molecular Biology. 2023; 45(7):5598-5612. https://doi.org/10.3390/cimb45070353
Chicago/Turabian StyleGuo, Manli, Lijie Zhang, Huihui Wang, Qiaozhen Zhou, Xinrang Zhu, Xinyu Fu, Jinlong Yang, Shanhe Liu, Dingcheng Guo, and Baoping Zhang. 2023. "SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas" Current Issues in Molecular Biology 45, no. 7: 5598-5612. https://doi.org/10.3390/cimb45070353
APA StyleGuo, M., Zhang, L., Wang, H., Zhou, Q., Zhu, X., Fu, X., Yang, J., Liu, S., Guo, D., & Zhang, B. (2023). SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas. Current Issues in Molecular Biology, 45(7), 5598-5612. https://doi.org/10.3390/cimb45070353