TRPM8 Puts the Chill on Prostate Cancer
AbstractProstate cancer (PCa) is one of the most frequently diagnosed cancers in developed countries. Several studies suggest that variations in calcium homeostasis are involved in carcinogenesis. Interestingly, (Transient Receptor Potential Melastatin member 8) TRPM8 calcium permeable channel expression is differentially regulated during prostate carcinogenesis, thereby suggesting a potential functional role for this channel in those cell processes, which are important for PCa evolution. Indeed, several studies have shown that TRPM8 plays a key role in processes such as the proliferation, viability and cell migration of PCa cells. Where cell migration is concerned, TRPM8 seems to have a protective anti-invasive effect and could be a particularly promising therapeutic target. The goal of this review is to inventory advances in understanding of the role of TRPM8 in the installation and progression of PCa. View Full-Text
A printed edition of this Special Issue is available here.
Share & Cite This Article
Grolez, G.P.; Gkika, D. TRPM8 Puts the Chill on Prostate Cancer. Pharmaceuticals 2016, 9, 44.
Grolez GP, Gkika D. TRPM8 Puts the Chill on Prostate Cancer. Pharmaceuticals. 2016; 9(3):44.Chicago/Turabian Style
Grolez, Guillaume P.; Gkika, Dimitra. 2016. "TRPM8 Puts the Chill on Prostate Cancer." Pharmaceuticals 9, no. 3: 44.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.