Next Article in Journal
Characterization of Antimicrobial Peptides toward the Development of Novel Antibiotics
Previous Article in Journal
Personalizing Colon Cancer Therapeutics: Targeting Old and New Mechanisms of Action
Previous Article in Special Issue
Toxicity Studies on Novel N-Substituted Bicyclo-Heptan-2-Amines at NMDA Receptors
Open AccessReview

Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade

Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
Authors to whom correspondence should be addressed.
Pharmaceuticals 2013, 6(8), 1039-1054;
Received: 29 May 2013 / Revised: 6 August 2013 / Accepted: 19 August 2013 / Published: 21 August 2013
(This article belongs to the Special Issue NMDA Receptor Antagonists for Treatment of CNS Disorders)
NMDA receptor (NMDA-R) is an important molecular entity governing a wide range of functions in the central nervous system. For example, the NMDA-R is involved in memory and cognition, and impairment of both (as in Alzheimer’s Disease) is attributed to NMDA-mediated neurotoxicity. With greater understanding of the NMDA-R structure, antagonists with varying degrees of binding-site and subtype selectivity have been developed and put into clinical use. Discovery of target-specific Chinese herbs have also been made in parallel. This article provides an overview of the known active sites on the NMDA-R, followed by a discussion of the relevant herbs and their constituents. Experimental evidence supporting the inhibitory role of the herbal compounds on the NMDA-R is highlighted. For some of the compounds, potential research directions are also proposed to further elucidate the underlying mechanisms of the herbs. It is envisaged that future investigations based on the present data will allow more clinically relevant herbs to be identified. View Full-Text
Keywords: NMDA receptor; antagonist; herb; Chinese medicine NMDA receptor; antagonist; herb; Chinese medicine
MDPI and ACS Style

Liang, W.; Lam, W.P.; Tang, H.C.; Leung, P.C.; Yew, D.T. Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade. Pharmaceuticals 2013, 6, 1039-1054.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop