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The Vasohibin Family

Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Pharmaceuticals 2010, 3(2), 433-440; https://doi.org/10.3390/ph3020433
Received: 13 January 2010 / Revised: 23 January 2010 / Accepted: 3 February 2010 / Published: 5 February 2010
(This article belongs to the Special Issue Angiogenesis Inhibitors)
Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is mostly extrinsic to the vasculature. Recently, however, vascular endothelial cells themselves have been found to produce angiogenesis inhibitors including vasohibin-1. These intrinsic inhibitors are thought to regulate angiogenesis by an auto-regulatory or negative-feedback mechanism. This review will focus on vasohibin-1 produced by vascular endothelial cells and on its homologue, vasohibin-2. View Full-Text
Keywords: endothelial cell; negative feedback; mononuclear cell; bone marrow endothelial cell; negative feedback; mononuclear cell; bone marrow
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Sato, Y. The Vasohibin Family. Pharmaceuticals 2010, 3, 433-440.

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