Next Article in Journal
Fusion of a Short HA2-Derived Peptide Sequence to Cell-Penetrating Peptides Improves Cytosolic Uptake, but Enhances Cytotoxic Activity
Next Article in Special Issue
Hypertensive Emergency in Aortic Dissection and Thoracic Aortic Aneurysm—A Review of Management
Previous Article in Journal
Antitumor Activity of Some Prenylated Xanthones
Open AccessOpinion

Antihypertensive Drug and Inner Ear Perfusion: An Otologist’s Point of View

Department of Specialist Surgical and Anesthesiological Sciences, University of Bologna, via Massarenti 9 – 40138 Bologna, Italy
Pharmaceuticals 2009, 2(2), 44-48; https://doi.org/10.3390/ph2020044
Received: 23 July 2009 / Revised: 4 September 2009 / Accepted: 11 September 2009 / Published: 11 September 2009
(This article belongs to the Special Issue Antihypertensive Drugs)
A number of labyrinthine disorders with sensorineural hearing loss, vertigo, and tinnitus are known to occur to young people without vascular risk factors, thus being classified as “idiopathic” in the absence of satisfactory explanations; in the last decade, this phenomenon has found a reliable explanation by the adverse effect of a sharp decrease of blood pressure values followed by an abnormal vasomotor regulation. This model may not only be applied to healthy subjects, but even had some confirmation in conditions possibly affecting hemodynamic changes, such as heart failure or treated hypertension. In particular, the results of a recent study on the impact of different antihypertensive therapies, which was analyzed by monitoring the onset or enhancement of tinnitus as a symptom of inner ear sufferance, unequivocally demonstrated an increased prevalence of tinnitus in subjects submitted to more “aggressive” treatments. This seems in agreement with recent observations about the model of fluid homeostasis of the inner ear, and suggests, when possible, to resort to treatments with modulatory effects in order to maintain a steady perfusion to the labyrinth thus protecting its function. View Full-Text
Keywords: inner ear perfusion; hemodinamic imbalance; antihypertensive therapy inner ear perfusion; hemodinamic imbalance; antihypertensive therapy
MDPI and ACS Style

Pirodda, A. Antihypertensive Drug and Inner Ear Perfusion: An Otologist’s Point of View. Pharmaceuticals 2009, 2, 44-48.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop