The Development of a Smart Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer Contrast Agent for the Imaging of Sulfatase Activity
Abstract
:1. Introduction
2. Results
2.1. Design and Synthesis of Contrast Agents 1-Gd and 1-Yb
2.2. Enzymatic Hydrolysis
2.3. A Fast Field Cycling NMR Relaxometry Analysis of MRI Contrast Agent 1-Gd
2.4. Z-Spectra Activity Analysis of 1-Yb for CEST Applications
3. Discussion
4. Materials and Methods
4.1. Synthetic Procedures and Spectroscopic Data
4.2. Enzymatic Hydrolysis
4.3. FFC Relaxometry
4.4. Z-spectra
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Welleman, I.M.; Reeβing, F.; Boersma, H.H.; Dierckx, R.A.J.O.; Feringa, B.L.; Szymanski, W. The Development of a Smart Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer Contrast Agent for the Imaging of Sulfatase Activity. Pharmaceuticals 2023, 16, 1439. https://doi.org/10.3390/ph16101439
Welleman IM, Reeβing F, Boersma HH, Dierckx RAJO, Feringa BL, Szymanski W. The Development of a Smart Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer Contrast Agent for the Imaging of Sulfatase Activity. Pharmaceuticals. 2023; 16(10):1439. https://doi.org/10.3390/ph16101439
Chicago/Turabian StyleWelleman, Ilse M., Friederike Reeβing, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Ben L. Feringa, and Wiktor Szymanski. 2023. "The Development of a Smart Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer Contrast Agent for the Imaging of Sulfatase Activity" Pharmaceuticals 16, no. 10: 1439. https://doi.org/10.3390/ph16101439