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The Age of Phage: Friend or Foe in the New Dawn of Therapeutic and Biocontrol Applications?
Case Report

Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy

1
Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
2
Department of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
3
PhagoMed Biopharma GmbH, 1110 Vienna, Austria
4
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Stephen T. Abedon and Diana R. Alves
Pharmaceuticals 2021, 14(3), 231; https://doi.org/10.3390/ph14030231
Received: 17 February 2021 / Revised: 4 March 2021 / Accepted: 5 March 2021 / Published: 8 March 2021
(This article belongs to the Special Issue Phage Therapy and Phage-Mediated Biological Control 2021)
Here, we present a case of a 79-year-old female with a recalcitrant Staphylococcal epidermidis prosthetic knee infection that was successfully treated with a single dose of adjuvant intra-articular bacteriophage therapy after debridement and implant retention surgery. The bacteriophage used in this case, PM448, is the first ɛ2 bacteriophage to be used in vivo. Currently the patient is without evidence of clinical recurrence and, interestingly, the patient had also suffered from debilitating aplastic anemia for over 2 years, which is recovering since receiving adjuvant bacteriophage therapy. View Full-Text
Keywords: Staphylococcus epidermidis; periprosthetic joint infection; bacteriophage therapy; biofilm; aplastic anemia Staphylococcus epidermidis; periprosthetic joint infection; bacteriophage therapy; biofilm; aplastic anemia
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MDPI and ACS Style

Doub, J.B.; Ng, V.Y.; Wilson, E.; Corsini, L.; Chan, B.K. Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy. Pharmaceuticals 2021, 14, 231. https://doi.org/10.3390/ph14030231

AMA Style

Doub JB, Ng VY, Wilson E, Corsini L, Chan BK. Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy. Pharmaceuticals. 2021; 14(3):231. https://doi.org/10.3390/ph14030231

Chicago/Turabian Style

Doub, James B., Vincent Y. Ng, Eleanor Wilson, Lorenzo Corsini, and Benjamin K. Chan 2021. "Successful Treatment of a Recalcitrant Staphylococcus epidermidis Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy" Pharmaceuticals 14, no. 3: 231. https://doi.org/10.3390/ph14030231

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