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Article

Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing

1
Department of Ophthalmology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan
2
Department of Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Luigi Brunetti
Pharmaceuticals 2021, 14(2), 88; https://doi.org/10.3390/ph14020088
Received: 16 December 2020 / Revised: 21 January 2021 / Accepted: 22 January 2021 / Published: 25 January 2021
The effects of each subtype-selective peroxisome proliferator activated receptor (PPAR) agonist (α, β/δ, γ) on corneal epithelial wound healing were investigated using a rat corneal alkali burn model. After the alkali burn, each PPAR agonist or vehicle ophthalmic solution was instilled topically onto the rat’s cornea. Corneal epithelial healing processes were evaluated by fluorescein staining. Pathological analyses and real-time reverse transcription polymerase chain reactions were performed to evaluate Ki67 (proliferative maker) expression and inflammatory findings. The area of the corneal epithelial defect at 12 h and 24 h after the alkali burn was significantly smaller in each PPAR group than in the vehicle group. Ki67 mRNA expression was increased in the PPARβ/δ group, whereas mRNA expressions of inflammatory cytokines were suppressed in all of the PPAR agonist groups. Nuclear factor kappa B (NF-κB) was the most suppressed in the PPARγ group. The accelerated corneal epithelial healing effects of each PPAR ligand were thought to be related to the promotion of proliferative capacity and inhibition of inflammation. View Full-Text
Keywords: corneal epithelial wound healing; PPAR; alkali burn corneal epithelial wound healing; PPAR; alkali burn
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MDPI and ACS Style

Tobita, Y.; Arima, T.; Nakano, Y.; Uchiyama, M.; Shimizu, A.; Takahashi, H. Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing. Pharmaceuticals 2021, 14, 88. https://doi.org/10.3390/ph14020088

AMA Style

Tobita Y, Arima T, Nakano Y, Uchiyama M, Shimizu A, Takahashi H. Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing. Pharmaceuticals. 2021; 14(2):88. https://doi.org/10.3390/ph14020088

Chicago/Turabian Style

Tobita, Yutaro, Takeshi Arima, Yuji Nakano, Masaaki Uchiyama, Akira Shimizu, and Hiroshi Takahashi. 2021. "Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing" Pharmaceuticals 14, no. 2: 88. https://doi.org/10.3390/ph14020088

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