Next Article in Journal
From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges
Next Article in Special Issue
Exploring Herbal Medicine Use during Palliative Cancer Care: The Integrative Physician as a Facilitator of Pharmacist–Patient–Oncologist Communication
Previous Article in Journal
Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study
Previous Article in Special Issue
Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells
Open AccessFeature PaperArticle

Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects among Palliative Cancer Patients

1
Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
2
Department of Oncology, Galilee Medical Center, Nahariya 22100, Israel
3
Cancer Center, Emek Medical Center, Afula 18101, Israel
4
Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 32000, Israel
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(12), 435; https://doi.org/10.3390/ph13120435
Received: 14 November 2020 / Revised: 25 November 2020 / Accepted: 27 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Supportive and Palliative Cancer Treatment)
In the last decade the use of medical cannabis (MC) for palliative cancer treatment has risen. However, the choice between products is arbitrary and most patients are using Tetrahydrocannabinol (THC)-dominant cannabis products. In this study, we aimed to assess the short-term outcomes of MC treatment prescribed by oncologists in relation to the type of cannabis they receive. A comparative analysis was used to assess the differences in treatment effectiveness and safety between THC-dominant (n = 56, 52%), cannabidiol (CBD)-dominant (n = 19, 18%), and mixed (n = 33, 30%) MC treatments. Oncology patients (n = 108) reported on multiple symptoms in baseline questionnaires, initiated MC treatment, and completed a one-month follow-up. Most parameters improved significantly from baseline, including pain intensity, affective and sensory pain, sleep quality and duration, cancer distress, and both physical and psychological symptom burden. There was no significant difference between the three MC treatments in the MC-related safety profile. Generally, there were no differences between the three MC treatments in pain intensity and in most secondary outcomes. Unexpectedly, CBD-dominant oil treatments were similar to THC-dominant treatments in their beneficial effects for most secondary outcomes. THC-dominant treatments showed significant superiority in their beneficial effect only in sleep duration compared to CBD-dominant treatments. This work provides evidence that, though patients usually consume THC-dominant products, caregivers should also consider CBD-dominant products as a useful treatment for cancer-related symptoms. View Full-Text
Keywords: medical cannabis; THC; CBD; palliative cancer treatment; oncology medical cannabis; THC; CBD; palliative cancer treatment; oncology
Show Figures

Figure 1

MDPI and ACS Style

Aviram, J.; Lewitus, G.M.; Vysotski, Y.; Uribayev, A.; Procaccia, S.; Cohen, I.; Leibovici, A.; Abo-Amna, M.; Akria, L.; Goncharov, D.; Mativ, N.; Kauffman, A.; Shai, A.; Hazan, O.; Bar-Sela, G.; Meiri, D. Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects among Palliative Cancer Patients. Pharmaceuticals 2020, 13, 435. https://doi.org/10.3390/ph13120435

AMA Style

Aviram J, Lewitus GM, Vysotski Y, Uribayev A, Procaccia S, Cohen I, Leibovici A, Abo-Amna M, Akria L, Goncharov D, Mativ N, Kauffman A, Shai A, Hazan O, Bar-Sela G, Meiri D. Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects among Palliative Cancer Patients. Pharmaceuticals. 2020; 13(12):435. https://doi.org/10.3390/ph13120435

Chicago/Turabian Style

Aviram, Joshua; Lewitus, Gil M.; Vysotski, Yelena; Uribayev, Anton; Procaccia, Shiri; Cohen, Idan; Leibovici, Anca; Abo-Amna, Mahmud; Akria, Luiza; Goncharov, Dmitry; Mativ, Neomi; Kauffman, Avia; Shai, Ayelet; Hazan, Or; Bar-Sela, Gil; Meiri, David. 2020. "Short-Term Medical Cannabis Treatment Regimens Produced Beneficial Effects among Palliative Cancer Patients" Pharmaceuticals 13, no. 12: 435. https://doi.org/10.3390/ph13120435

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop