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Open AccessFeature PaperArticle

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy
2
Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2031, Australia
3
ARC Centre of Excellence for Convergent BioNano Science and Technology, Australian Centre for NanoMedicine, UNSW, Sydney, NSW 2052, Australia
4
School of Women’s and Children’s Health, Faculty of Medicine, UNSW, Sydney, NSW 2052, Australia
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(1), 2; https://doi.org/10.3390/ph13010002
Received: 26 November 2019 / Revised: 12 December 2019 / Accepted: 19 December 2019 / Published: 25 December 2019
With the aim to effectively deliver methotrexate (MTX) to breast cancer cells, we designed a nanocarrier system (DC) derived from the self-assembly of a dextran-curcumin conjugate prepared via enzyme chemistry with immobilized laccase acting as a solid biocatalyst. Nanoparticles consisted of homogeneously dispersed nanospheres with a mean diameter of 290 nm, as characterized by combined transmission electron microscopy and dynamic light scattering investigations. DC was able to control the MTX release overtime (t1/2 value of 310 min), with cell internalization studies proving its presence inside MCF-7 cytoplasm. Finally, improved MTX efficacy was obtained in viability assays, and attributed to the synergy of curcumin moieties and loaded MTX as underlined by a combination index (CI) < 1. View Full-Text
Keywords: polyphenol conjugate; self-assembling nanoparticles; curcumin; breast cancer; synergism polyphenol conjugate; self-assembling nanoparticles; curcumin; breast cancer; synergism
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Curcio, M.; Cirillo, G.; Tucci, P.; Farfalla, A.; Bevacqua, E.; Vittorio, O.; Iemma, F.; Nicoletta, F.P. Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy. Pharmaceuticals 2020, 13, 2.

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