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Ion-Sensitive Field-Effect Transistor for Biological Sensing

BioNanotechnology Research Center (BNRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-333, Korea
School of Engineering, University of Science and Technology (UST), Daejeon 305-333, Korea
Author to whom correspondence should be addressed.
Sensors 2009, 9(9), 7111-7131;
Received: 4 August 2009 / Revised: 27 August 2009 / Accepted: 31 August 2009 / Published: 7 September 2009
(This article belongs to the Special Issue ISFET Sensors)
PDF [484 KB, uploaded 21 June 2014]


In recent years there has been great progress in applying FET-type biosensors for highly sensitive biological detection. Among them, the ISFET (ion-sensitive field-effect transistor) is one of the most intriguing approaches in electrical biosensing technology. Here, we review some of the main advances in this field over the past few years, explore its application prospects, and discuss the main issues, approaches, and challenges, with the aim of stimulating a broader interest in developing ISFET-based biosensors and extending their applications for reliable and sensitive analysis of various biomolecules such as DNA, proteins, enzymes, and cells. View Full-Text
Keywords: ISFET; ion-sensitive field-effect transistor; biosensor; biomolecules ISFET; ion-sensitive field-effect transistor; biosensor; biomolecules
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, C.-S.; Kim, S.K.; Kim, M. Ion-Sensitive Field-Effect Transistor for Biological Sensing. Sensors 2009, 9, 7111-7131.

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