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Quantitative 2D Magnetorelaxometry Imaging of Magnetic Nanoparticles Using Optically Pumped Magnetometers

1
Institute of Electrical and Biomedical Engineering, UMIT—Private University for Health Sciences, Medical Informatics and Technology, 6060 Hall in Tirol, Austria
2
Department Biosignals, PTB—Physikalisch-Technische Bundesanstalt, 10587 Berlin, Germany
3
Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, 98693 Ilmenau, Germany
*
Author to whom correspondence should be addressed.
Sensors 2020, 20(3), 753; https://doi.org/10.3390/s20030753
Received: 30 December 2019 / Revised: 23 January 2020 / Accepted: 27 January 2020 / Published: 29 January 2020
(This article belongs to the Section Biomedical Sensors)
For biomagnetical applications exploiting physical properties of magnetic nanoparticles (MNP), e.g., magnetic hyperthermia, knowledge about the quantitative spatial MNP distribution is crucial, which can be extracted by magnetorelaxometry (MRX) imaging. In this paper, we present quantification, quantitative 1D reconstruction, and quantitative 2D imaging of MNP by exploiting optically pumped magnetometers for MRX. While highlighting the potential of commercially available optically pumped magnetometers (OPM) for MRXI, we discuss current limitations of the used OPM. We show, that with our OPM setup, MNP can be precisely quantified with iron amounts down to ≈6 μg, which can be improved easily. With a 1D-reconstruction setup, point-like and complex MNP phantoms can be reconstructed quantitatively with high precision and accuracy. We show that with our developed 2D MRX imaging setup, which measures 12 cm by 8 cm, point-like MNP distributions with clinically relevant iron concentrations can be reconstructed precisely and accurately. Our 2D setup has the potential to be easily extended to a tomography styled (and thus slice-selective) 3D scanner, by adding a mechanical axis to the phantom. View Full-Text
Keywords: magnetic nanoparticles; optically pumped magnetometers; magnetorelaxometry imaging magnetic nanoparticles; optically pumped magnetometers; magnetorelaxometry imaging
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MDPI and ACS Style

Jaufenthaler, A.; Schier, P.; Middelmann, T.; Liebl, M.; Wiekhorst, F.; Baumgarten, D. Quantitative 2D Magnetorelaxometry Imaging of Magnetic Nanoparticles Using Optically Pumped Magnetometers. Sensors 2020, 20, 753. https://doi.org/10.3390/s20030753

AMA Style

Jaufenthaler A, Schier P, Middelmann T, Liebl M, Wiekhorst F, Baumgarten D. Quantitative 2D Magnetorelaxometry Imaging of Magnetic Nanoparticles Using Optically Pumped Magnetometers. Sensors. 2020; 20(3):753. https://doi.org/10.3390/s20030753

Chicago/Turabian Style

Jaufenthaler, Aaron, Peter Schier, Thomas Middelmann, Maik Liebl, Frank Wiekhorst, and Daniel Baumgarten. 2020. "Quantitative 2D Magnetorelaxometry Imaging of Magnetic Nanoparticles Using Optically Pumped Magnetometers" Sensors 20, no. 3: 753. https://doi.org/10.3390/s20030753

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