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Open AccessArticle

An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives

1
Research and Development Center for Five-Sense Devices, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan
2
JST, ImPACT, Sanban-cho 5, Chiyoda-ku, Tokyo 102-0075, Japan
3
Graduate School of Information Science and Electrical Engineering, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan
4
Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8552, Japan
5
Institute for Advanced Study, Kyushu University, 744 Motooka, Nishiku, Fukuoka 819-0395, Japan
*
Author to whom correspondence should be addressed.
Sensors 2018, 18(12), 4461; https://doi.org/10.3390/s18124461
Received: 20 November 2018 / Revised: 13 December 2018 / Accepted: 15 December 2018 / Published: 17 December 2018
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)
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Abstract

In this study, we developed a surface plasmon resonance (SPR) sensor chip based on 2,4,6-trinitrotoluene (TNT) recognition peptide-modified single-walled carbon nanotubes (SWCNTs). The carboxylic acid-functionalized SWCNTs were immobilized on a 3-aminopropyltriethoxysilane (APTES)-modified SPR Au chip surface. Through π-stacking between the aromatic amino acids and SWCNTs, the TNT recognition peptide TNTHCDR3 was immobilized onto the surface of the SWCNTs. The peptide–SWCNTs-modified sensor surface was confirmed and evaluated by atomic force microscope (AFM) observation. The peptide–SWCNTs hybrid SPR sensor chip exhibited enhanced sensitivity with a limit of detection (LOD) of 772 ppb and highly selective detection compared with commercialized carboxymethylated dextran matrix sensor chips. View Full-Text
Keywords: SPR; TNTHCDR3; SWCNTs; π-stacking; TNT analogues SPR; TNTHCDR3; SWCNTs; π-stacking; TNT analogues
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wang, J.; Du, S.; Onodera, T.; Yatabe, R.; Tanaka, M.; Okochi, M.; Toko, K. An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives. Sensors 2018, 18, 4461.

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