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Advances in Testing Techniques for Digital Microfluidic Biochips

Electrical & Electronic Engineering Department, Centre for Intelligent Signal and Imaging Research (CISIR), Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia
Waham Technologies, Subang Jaya, 47600 Selangor Darul Ehsan, Malaysia
Author to whom correspondence should be addressed.
Sensors 2017, 17(8), 1719;
Received: 5 May 2017 / Revised: 8 July 2017 / Accepted: 18 July 2017 / Published: 27 July 2017
(This article belongs to the Special Issue Microfluidic Sensors and Control Devices)
PDF [1305 KB, uploaded 27 July 2017]


With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA)-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revised/new testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips. View Full-Text
Keywords: digital microfluidics; testing; reliability; MEDA; droplet; biochips digital microfluidics; testing; reliability; MEDA; droplet; biochips

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Shukla, V.; Hussin, F.A.; Hamid, N.H.; Zain Ali, N.B. Advances in Testing Techniques for Digital Microfluidic Biochips. Sensors 2017, 17, 1719.

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