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Sensors 2017, 17(10), 2316; https://doi.org/10.3390/s17102316

Recent Advances in Nanoparticle Concentration and Their Application in Viral Detection Using Integrated Sensors

1
School of Engineering and Computer Science, Washington State University, Vancouver, WA 98686, USA
2
George W. Woodruff School of Mechanical Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, GA 30313, USA
3
Bioengineering Program, Petit Institute for Bioengineering and Bioscience, Center for Flexible Electronics, Institute for Engineering and Nanotechnology, Institute for Bioengineering & Bioscience, Neural Engineering Center, Georgia Institute of Technology, Atlanta, GA 30332, USA
*
Authors to whom correspondence should be addressed.
Received: 30 August 2017 / Revised: 2 October 2017 / Accepted: 4 October 2017 / Published: 11 October 2017
(This article belongs to the Special Issue Sensors for Health Monitoring and Disease Diagnosis)
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Abstract

Early disease diagnostics require rapid, sensitive, and selective detection methods for target analytes. Specifically, early viral detection in a point-of-care setting is critical in preventing epidemics and the spread of disease. However, conventional methods such as enzyme-linked immunosorbent assays or cell cultures are cumbersome and difficult for field use due to the requirements of extensive lab equipment and highly trained personnel, as well as limited sensitivity. Recent advances in nanoparticle concentration have given rise to many novel detection methodologies, which address the shortcomings in modern clinical assays. Here, we review the primary, well-characterized methods for nanoparticle concentration in the context of viral detection via diffusion, centrifugation and microfiltration, electric and magnetic fields, and nano-microfluidics. Details of the concentration mechanisms and examples of related applications provide valuable information to design portable, integrated sensors. This study reviews a wide range of concentration techniques and compares their advantages and disadvantages with respect to viral particle detection. We conclude by highlighting selected concentration methods and devices for next-generation biosensing systems. View Full-Text
Keywords: biosensors; nanoparticle concentration; viral detection; sensitivity; selectivity biosensors; nanoparticle concentration; viral detection; sensitivity; selectivity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Dincau, B.M.; Lee, Y.; Kim, J.-H.; Yeo, W.-H. Recent Advances in Nanoparticle Concentration and Their Application in Viral Detection Using Integrated Sensors. Sensors 2017, 17, 2316.

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