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Sensors 2017, 17(10), 2272;

Automated Dielectrophoretic Tweezers-Based Force Spectroscopy System in a Microfluidic Device

Department of Biomedical Engineering, Yonsei University, Wonju 220-710, Korea
Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea
Department of Biomedical Engineering, University of Science and Technology, Daejeon 305-350, Korea
Department of Bio-Convergence, Korea University, Seoul 136-701, Korea
Mechanical Engineering Department, University of Wisconsin-Milwaukee, 3200 N Cramer St., Milwaukee, WI 53211, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 2 August 2017 / Revised: 22 September 2017 / Accepted: 29 September 2017 / Published: 4 October 2017
(This article belongs to the Special Issue Biomedical Sensors and Systems 2017)
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We reported an automated dielectrophoretic (DEP) tweezers-based force spectroscopy system to examine intermolecular weak binding interactions, which consists of three components: (1) interdigitated electrodes and micro-sized polystyrene particles used as DEP tweezers and probes inside a microfluidic device, along with an arbitrary function generator connected to a high voltage amplifier; (2) microscopy hooked up to a high-speed charge coupled device (CCD) camera with an image acquisition device; and (3) a computer aid control system based on the LabVIEW program. Using this automated system, we verified the measurement reliability by measuring intermolecular weak binding interactions, such as hydrogen bonds and Van der Waals interactions. In addition, we also observed the linearity of the force loading rates, which is applied to the probes by the DEP tweezers, by varying the number of voltage increment steps and thus affecting the linearity of the force loading rates. This system provides a simple and low-cost platform to investigate intermolecular weak binding interactions. View Full-Text
Keywords: dielectrophoresis; force spectroscopy; force loading rate; intermolecular weak binding interactions dielectrophoresis; force spectroscopy; force loading rate; intermolecular weak binding interactions

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Kim, M.H.; Lee, J.; Nam, K.; Park, I.S.; Son, M.; Ko, H.; Lee, S.; Yoon, D.S.; Chang, W.-J.; Lee, S.Y.; Yoon, Y.R.; Lee, S.W. Automated Dielectrophoretic Tweezers-Based Force Spectroscopy System in a Microfluidic Device. Sensors 2017, 17, 2272.

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