Next Article in Journal
An Algorithm for Retrieving Land Surface Temperatures Using VIIRS Data in Combination with Multi-Sensors
Previous Article in Journal
Using Floating Car Data to Analyse the Effects of ITS Measures and Eco-Driving
Previous Article in Special Issue
CMOS Time-Resolved, Contact, and Multispectral Fluorescence Imaging for DNA Molecular Diagnostics
Article Menu

Export Article

Open AccessArticle
Sensors 2014, 14(11), 21375-21384;

Synthesis of a Cu2+-Selective Probe Derived from Rhodamine and Its Application in Cell Imaging

Laboratory of Environmental Monitoring, School of Tropical and Laboratory Medicine, Hainan Medical University, Haikou 571199, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 15 August 2014 / Revised: 4 November 2014 / Accepted: 5 November 2014 / Published: 12 November 2014
(This article belongs to the Special Issue Molecular Sensing and Molecular Electronics)
Full-Text   |   PDF [2200 KB, uploaded 12 November 2014]   |  


A new fluorescent probe P based on rhodamine for Cu2+ was synthesized and characterized. The new probe P showed high selectivity to Cu2+ over other tested metal ions. With optimal conditions, the proposed probe P worked in a wide linear range of 1.0 × 106–1.0 × 105 M with a detection limit of 3.3 × 10−7 M Cu2+ in ethanol-water solution (9:1, v:v, 20 mM HEPES, pH 7.0). Furthermore, it has been used for imaging of Cu2+ in living cells with satisfying results. View Full-Text
Keywords: rhodamine derivative; fluorescence enhancement; fluorescence imaging rhodamine derivative; fluorescence enhancement; fluorescence imaging

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Yu, C.; Wen, Y.; Zhang, J. Synthesis of a Cu2+-Selective Probe Derived from Rhodamine and Its Application in Cell Imaging. Sensors 2014, 14, 21375-21384.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top