Next Article in Journal
A Time Tree Medium Access Control for Energy Efficiency and Collision Avoidance in Wireless Sensor Networks
Next Article in Special Issue
A Multiwell Electrochemical Biosensor for Real-Time Monitoring of the Behavioural Changes of Cells in Vitro
Previous Article in Journal
In/Out Status Monitoring in Mobile Asset Tracking with Wireless Sensor Networks
Previous Article in Special Issue
Whispering Gallery Modes in Standard Optical Fibres for Fibre Profiling Measurements and Sensing of Unlabelled Chemical Species
Article Menu

Export Article

Open AccessReview
Sensors 2010, 10(4), 2731-2751;

Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation

Department of Cardiology, The Rayne Institute, King’s College London, St. Thomas’ Hospital, London, SE1 7EH, UK
Author to whom correspondence should be addressed.
Received: 11 January 2010 / Revised: 19 March 2010 / Accepted: 22 March 2010 / Published: 26 March 2010
(This article belongs to the Special Issue State-of-the-Art Sensors Technology in the UK)
Full-Text   |   PDF [3567 KB, uploaded 21 June 2014]


The control of vascular smooth muscle contractility enables regulation of blood pressure, which is paramount in physiological adaptation to environmental challenges. Maintenance of stable blood pressure is crucial for health as deregulation (caused by high or low blood pressure) leads to disease progression. Vasotone is principally controlled by the cyclic nucleotide dependent protein kinases A and G, which regulate intracellular calcium and contractile protein calcium sensitivity. The classical pathways for activation of these two kinases are well established and involve the formation and activation by specific cyclic nucleotide second messengers. Recently we reported that both PKA and PKG can be regulated independently of their respective cyclic nucleotides via a mechanism whereby the kinases sense cellular oxidant production using redox active thiols. This novel redox regulation of these kinases is potentially of physiological importance, and may synergise with the classical regulatory mechanisms. View Full-Text
Keywords: protein kinase A; protein kinase G; oxidation protein kinase A; protein kinase G; oxidation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Burgoyne, J.R.; Eaton, P. Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation. Sensors 2010, 10, 2731-2751.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top