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Short Note

(S)-3-(3-((7-Ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile

1
Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany
2
Department of Chemistry, Johannes Gutenberg-Universität Mainz, Duesbergweg 10–14, 55128 Mainz, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Oleg A. Rakitin
Molbank 2022, 2022(3), M1437; https://doi.org/10.3390/M1437
Received: 18 July 2022 / Revised: 25 August 2022 / Accepted: 26 August 2022 / Published: 31 August 2022
(This article belongs to the Section Organic Synthesis)
The title compound (S)-3-(3-((7-ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile (2) was synthesized in five steps, starting from 4-chloro-7-iodo-9H-pyrimido[4,5-b]indole (3), and was characterized by 1H-NMR, 13C-NMR, MS and HPLC. Moreover, its structure was confirmed by single crystal X-ray diffraction. Pyrimido[4,5-b]indole 2 demonstrated an IC50 value of 2.24 µM in a NanoBRETTM TE intracellular glycogen synthase kinase-3β assay. View Full-Text
Keywords: kinase inhibitor; glycogen synthase kinase 3β; tricyclic heterocycle; pyrimido[4,5-b]indole; single crystal diffraction kinase inhibitor; glycogen synthase kinase 3β; tricyclic heterocycle; pyrimido[4,5-b]indole; single crystal diffraction
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MDPI and ACS Style

Andreev, S.; Plank, N.; Schollmeyer, D.; Koch, P. (S)-3-(3-((7-Ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile. Molbank 2022, 2022, M1437. https://doi.org/10.3390/M1437

AMA Style

Andreev S, Plank N, Schollmeyer D, Koch P. (S)-3-(3-((7-Ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile. Molbank. 2022; 2022(3):M1437. https://doi.org/10.3390/M1437

Chicago/Turabian Style

Andreev, Stanislav, Nicole Plank, Dieter Schollmeyer, and Pierre Koch. 2022. "(S)-3-(3-((7-Ethynyl-9H-pyrimido[4,5-b]indol-4-yl)amino)piperidin-1-yl)propanenitrile" Molbank 2022, no. 3: M1437. https://doi.org/10.3390/M1437

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