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Short Note

Ethyl (E)-(3-(4-((4-bromobenzyl)oxy)phenyl)acryloyl)glycinate

Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Author to whom correspondence should be addressed.
Academic Editor: Stefano D’Errico
Molbank 2022, 2022(2), M1378;
Received: 24 May 2022 / Revised: 1 June 2022 / Accepted: 2 June 2022 / Published: 4 June 2022
In an attempt to develop new potent anti-inflammatory agents, a cinnamic -amino acid hybrid molecule was synthesized and in silico drug-likeness, in vitro COX-2 inhibition, and pharmacokinetic properties were studied. The results showed high cyclooxygenase inhibitory activity (IC50 = 6 µM) and favorable pharmacokinetic properties, being orally bioavailable according to Lipinski’s rule of five, making this compound a possible lead to design and develop potent COX inhibitors. The new compound, in comparison with its cinnamic acid precursor (E)-(3-(4-((4-bromobenzyl)oxy)phenyl)acrylic acid, showed improved biological activities. Compound ethyl (E)-(3-(4-((4-bromobenzyl)oxy)phenyl)acryloyl)glycinate can be used as a lead for the synthesis of more effective hybrids. View Full-Text
Keywords: cinnamic acid; amino acid; hybrids; COX-2 cinnamic acid; amino acid; hybrids; COX-2
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MDPI and ACS Style

Fotopoulos, I.; Papaioannou, G.-C.; Hadjipavlou-Litina, D. Ethyl (E)-(3-(4-((4-bromobenzyl)oxy)phenyl)acryloyl)glycinate. Molbank 2022, 2022, M1378.

AMA Style

Fotopoulos I, Papaioannou G-C, Hadjipavlou-Litina D. Ethyl (E)-(3-(4-((4-bromobenzyl)oxy)phenyl)acryloyl)glycinate. Molbank. 2022; 2022(2):M1378.

Chicago/Turabian Style

Fotopoulos, Ioannis, George-Christos Papaioannou, and Dimitra Hadjipavlou-Litina. 2022. "Ethyl (E)-(3-(4-((4-bromobenzyl)oxy)phenyl)acryloyl)glycinate" Molbank 2022, no. 2: M1378.

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