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Synthesis and Structure Determination of 1-(4-Methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide
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Mathematics, Natural, and Health Sciences Division, University of Hawaiʻi West Oʻahu, 91-1001 Farrington Hwy, Kapolei, HI 96707, USA
Author to whom correspondence should be addressed.
Academic Editor: Ian R. Baxendale
Molbank 2022, 2022(2), M1375;
Received: 17 May 2022 / Revised: 27 May 2022 / Accepted: 29 May 2022 / Published: 1 June 2022
Imidazole-containing chalcones have been shown to be effective against Aspergillus fumigatus, the pathogenic agent for pulmonary aspergillosis. Claisen-Schmidt condensation of 4-(1H-imidazol-1-yl)benzaldehyde with 3′-chloro-4′-fluoroacetophenone using aqueous sodium hydroxide in methanol yielded the novel compound (E)-3-[4-(1H-imidazol-1-yl)phenyl]-1-(3-chloro-4-fluorophenyl)prop-2-en-1-one in good purity after purification by silica gel column chromatography. This novel compound is suitable for testing the antifungal properties of the combined pharmacophores against Aspergillus and other pathogenic fungi. View Full-Text
Keywords: chalcone; synthesis; aldol; pulmonary aspergillosis; imidazole chalcone; synthesis; aldol; pulmonary aspergillosis; imidazole
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MDPI and ACS Style

Takaki, R.; Ashburn, B.O. (E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(3-chloro-4-fluorophenyl)prop-2-en-1-one. Molbank 2022, 2022, M1375.

AMA Style

Takaki R, Ashburn BO. (E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(3-chloro-4-fluorophenyl)prop-2-en-1-one. Molbank. 2022; 2022(2):M1375.

Chicago/Turabian Style

Takaki, Reina, and Bradley O. Ashburn. 2022. "(E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(3-chloro-4-fluorophenyl)prop-2-en-1-one" Molbank 2022, no. 2: M1375.

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