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Ethyl (S)-2-Benzamido-5-[(4,6-dimethylpyrimidin-2-yl)amino]pentanoate

1
Programa Regional de Posgrado en Biotecnología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Culiacán 80010, Sin., Mexico
2
Programa de Posgrado en Ciencias Biomédicas, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Culiacán 80010, Sin., Mexico
*
Author to whom correspondence should be addressed.
Molbank 2020, 2020(4), M1166; https://doi.org/10.3390/M1166
Received: 29 October 2020 / Revised: 12 November 2020 / Accepted: 12 November 2020 / Published: 13 November 2020
(This article belongs to the Special Issue Heterocycle Reactions)
Pyrimidines are compounds with a wide range of biological activities, and the synthesis of pyrimidine derivatives—useful in chemical and medicinal applications—is important in medicinal chemistry. This work shows the synthesis under microwave irradiation of the novel compound ethyl (S)-2-benzamido-5-[(4,6-dimethylpyrimidin-2-yl)amino]pentanoate (3) from (S)-N-α-benzoyl-l-arginine ethyl ester hydrochloride (1) and acetylacetone (2). Compound 3 was easily purified, obtained in moderate yield (70%), and fully characterized by UV-Vis, FTIR-ATR spectroscopy, 1H-NMR, 13C-NMR, HRMS, and EI-MS. View Full-Text
Keywords: pyrimidines; l-arginine; microwave irradiation pyrimidines; l-arginine; microwave irradiation
MDPI and ACS Style

Leyva-Acuña, M.A.; Delgado-Vargas, F.; López-Angulo, G.; Montes-Avila, J. Ethyl (S)-2-Benzamido-5-[(4,6-dimethylpyrimidin-2-yl)amino]pentanoate. Molbank 2020, 2020, M1166.

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