Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Kampus Bina Widya, Jalan H.R. Subrantas KM. 12.5, Pekanbaru 28293, Indonesia
Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi (STIFAR) Riau, Jalan Kamboja, Pekanbaru 28293, Indonesia
Author to whom correspondence should be addressed.
Molbank 2020, 2020(4), M1159; https://doi.org/10.3390/M1159
Received: 25 August 2020 / Revised: 4 October 2020 / Accepted: 5 October 2020 / Published: 8 October 2020
(This article belongs to the Section Organic Synthesis)
The 3,5-bis((E)-4-methoxybenzylidene)-1-(2-morpholinoethyl)piperidin-4-one (3) compound was synthesized by a two-step reaction with 92% yield. The chemical structure of compound 3 was confirmed by IR, NMR, and mass spectrometry. The title compound was screened for its anti-dengue activity against DENV2 NS2B-NS3 protease and showed 39.09% inhibitory activity at 200 µg/mL.