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A Convenient Four-Step Synthesis of 1-{β-[3-(4-Methoxy-phenyl)Propoxy]-4-Methoxyphenethyl}-1H-Imidazole Hydrochloride as a Probing Tool for SOCE Assays

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Institut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, groupe CORINT, Université de Rennes 1, Campus de Beaulieu, Bât. 10A, 263 Avenue du Général Leclerc, CS 74205, 35042 Rennes Cedex, France
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Laboratoire de Chimie Bio Organique et de Substances Naturelles (LCBOSN), Université Nangui Abrogoua (UNA), BP 802, Abidjan, Cote d’Ivoire
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Laboratoire Canalopathies & Signalisation Calcique, Inserm U1078, Université de Bretagne Occidentale, 22 Avenue Camille Desmoulins, 29200 Brest Cedex, France
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CalciScreen platform, Université de Bretagne Occidentale, 22 Avenue Camille Desmoulins, 29200 Brest Cedex, France
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S2 Wave platform SFS ScanMAT, Université de Rennes 1, Campus de Beaulieu, Bât. 10A, 263 Avenue du Général Leclerc, CS 74205, 35042 Rennes Cedex, France
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Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Molbank 2016, 2016(4), M909; https://doi.org/10.3390/M909
Received: 17 August 2016 / Revised: 16 September 2016 / Accepted: 19 September 2016 / Published: 22 September 2016
1-{β-[3-(4-Methoxy-phenyl)propoxy]-4-methoxyphenethyl}-1H-imidazole hydrochloride 7, or SKF-96365, was synthesized in four steps with an overall yield of 9%. The structure of 7 was confirmed by 1H-, 13C-NMR, HRMS, and elemental analysis. The intermediates 3 and 4 were also isolated and characterized by 1H-, 13C-NMR, and HRMS. View Full-Text
Keywords: SKF-96365; imidazole; modulator; SOCE SKF-96365; imidazole; modulator; SOCE
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Dago, C.D.; Messé, E.; Mignen, O.; Brigaudeau, C.; Békro, Y.-A.; Bazureau, J.-P. A Convenient Four-Step Synthesis of 1-{β-[3-(4-Methoxy-phenyl)Propoxy]-4-Methoxyphenethyl}-1H-Imidazole Hydrochloride as a Probing Tool for SOCE Assays. Molbank 2016, 2016, M909.

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