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2,3-Dimethylbenzoxazolium Methosulfate

Department of Pharmaceutical and Applied Organic Chemistry, Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski”, 1, blv. J. Bourchier, 1164 Sofia, Bulgaria
Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
Institute of Catalysis, Bulgarian Academy of Sciences, Acad. G. Bonchev St, Bldg 11, 1113 Sofia, Bulgaria
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Molbank 2016, 2016(1), M889;
Received: 4 February 2016 / Revised: 29 February 2016 / Accepted: 1 March 2016 / Published: 5 March 2016
PDF [327 KB, uploaded 5 March 2016]


An economically benign solvent-free approach to synthesise 2,3-dimethylbenzoxazolium methosulfate is reported in the present work. The title compound is derived from 2-methylbenzoxazole reacting with a slight excess of dimethylsulfate, at room temperature. The reaction proceeds via an intrinsic exothermic reaction, and the benzoxazolium salt crystallized after a short time into a white crystalline form. The product was filtered off and washed with acetone and diethyl ether to provide the desired product in 89% yield. The target compound was evaluated by ESI/MS analysis. View Full-Text
Keywords: 2-methylbenzoxazole; dimethylsulfate; 2,3-dimethylbenzoxazolium methosulfate 2-methylbenzoxazole; dimethylsulfate; 2,3-dimethylbenzoxazolium methosulfate

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kurutos, A.; Gadjev, N.; Šmidlehner, T.; Minkovska, S.; Piantanida, I.; Deligeorgiev, T. 2,3-Dimethylbenzoxazolium Methosulfate. Molbank 2016, 2016, M889.

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