7-{[2-(4-Hydroxyphenyl)methylidene]amino}-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
by
Ghulam Fareed 1,2,*, Mahboob A. Kalhoro 1, Muhammad A. Versiani 2, Nighat Afza 1 and Nazia Fareed 2
Ghulam Fareed 1,2,*, Mahboob A. Kalhoro 1, Muhammad A. Versiani 2, Nighat Afza 1 and Nazia Fareed 2
1
Pharmaceutical Research Center, PCSIR Laboratories Complex Karachi, Shahrah-e-Dr.Salim-uz-Zaman Siddiqui Karachi-75280. Sindh, Pakistan
2
Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Ghulshan-e-Iqbal, Karachi-75300. Sindh, Pakistan
*
Author to whom correspondence should be addressed.
Molbank 2012, 2012(2), M756; https://doi.org/10.3390/M756
Received: 27 March 2012 / Accepted: 2 May 2012 / Published: 10 May 2012
Novel 7-{[2-(4-hydroxyphenyl)methylidene]amino}-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid was prepared by condensation of ceftriaxone disodium (1) with 4-hydroxybenzaldehyde (2) in ethanol under reflux conditions for 3–4 h. The structure of synthesized compound was elucidated using LCMS, 1H-NMR, and CHN techniques.
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Keywords:
ceftriaxone; 4-hydroxybenzaldehyde
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MDPI and ACS Style
Fareed, G.; Kalhoro, M.A.; Versiani, M.A.; Afza, N.; Fareed, N. 7-{[2-(4-Hydroxyphenyl)methylidene]amino}-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid. Molbank 2012, 2012, M756.
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- Supplementary File 1:
3D structure (MOL, 4 KB)
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3D structure generated by CORINA by Molecular Networks. - Supplementary File 2:
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- Supplementary File 3:
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