In the original publication [], there was a mistake in Figure 6A. When the IVIS images of two mice in JK10 group day 17 were cropped from the original larger image to fit with the layout, a mistake occurred so that one JK10 mouse was replaced with a JK11 mouse. The analyzed data were correct; as were Figure 6B–D. Only the image of the individual mouse was wrong. The corrected Figure 6 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Figure 6.
CD28 and 4-1BB CAR T cells inhibit tumor growth in vivo. (A) Bioluminescence images of individual mice at multiple time points in a subcutaneous tumor model. NSG mice were engrafted subcutaneously on both hind legs with 2 × 106 luciferase expressing 22Rv1 prostate cancer cells. On days 10 and 17, the mice were treated with 1 × 107 non-transduced (NT) T cells (Ntumor = 6) or CD28 CAR T cells (Ntumor = 12) and 4-1BB CAR T cells (Ntumor = 12) by intravenous injection. Bioluminescence signals of individual mice were measured at indicated time points (days after tumor engraftment). (B) Tumor growth is measured once a week by bioluminescence IVIS imaging. The data are presented as the mean ± SEM of tumors in each group. (C) Bioluminescence signals (mean ± SEM) 38 days after tumor engraftment. Statistical analyses in (B,C) were performed with the Mann–Whitney U test. NS (not significant), ** p < 0.001. (D) The body weight of the mice was measured once per week after the first treatment with T cells on day 10. Error bars indicate SD.
Reference
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