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Review

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

1
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan
2
Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33305, Taiwan
3
Department of Medicine, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan
4
Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30012, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Rossana Morabito and Alessia Remigante
Int. J. Mol. Sci. 2022, 23(3), 1255; https://doi.org/10.3390/ijms23031255
Received: 16 December 2021 / Revised: 20 January 2022 / Accepted: 21 January 2022 / Published: 23 January 2022
Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases. View Full-Text
Keywords: oxidative stress; ocular diseases; antioxidant biomarkers; antioxidant therapy oxidative stress; ocular diseases; antioxidant biomarkers; antioxidant therapy
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MDPI and ACS Style

Hsueh, Y.-J.; Chen, Y.-N.; Tsao, Y.-T.; Cheng, C.-M.; Wu, W.-C.; Chen, H.-C. The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases. Int. J. Mol. Sci. 2022, 23, 1255. https://doi.org/10.3390/ijms23031255

AMA Style

Hsueh Y-J, Chen Y-N, Tsao Y-T, Cheng C-M, Wu W-C, Chen H-C. The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases. International Journal of Molecular Sciences. 2022; 23(3):1255. https://doi.org/10.3390/ijms23031255

Chicago/Turabian Style

Hsueh, Yi-Jen, Yen-Ning Chen, Yu-Ting Tsao, Chao-Min Cheng, Wei-Chi Wu, and Hung-Chi Chen. 2022. "The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases" International Journal of Molecular Sciences 23, no. 3: 1255. https://doi.org/10.3390/ijms23031255

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