Impaired Pain Processing at a Brainstem Level Is Involved in Maladaptive Neuroplasticity in Patients with Chronic Complex Regional Pain Syndrome
Abstract
:1. Introduction
2. Results
2.1. Demographics and Clinical Data
2.2. Blink Reflex Assessment—Differences between Patients with CRPS and Controls
2.3. Blink Reflex as a Potential Biomarker for CRPS
3. Discussion
3.1. Blink Reflex and Brainstem Involvement in CRPS Pathophysiology
3.2. Blink Reflex as a Potential Biomarker of CRPS
3.3. Limitations
4. Materials and Methods
4.1. Participants
4.2. Assessment of Demographics and Clinical Characteristics
4.3. Assessment of Nociceptive Blink Reflex Habituation and Sensitization
4.4. Data Evaluation
4.5. Sample Size Estimation and Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patient No | Age | Gender 1 | Affected Limb 2 | Inciting Event 3 | Time Onset 4 | Rpain 5 | Mpain 6 | CSS 7 | Medication 8 |
---|---|---|---|---|---|---|---|---|---|
1 | 22 | f | R | O | 58 | 6 | 7 | 15 | ABCD |
2 | 67 | f | R | CT | 120 | 5 | 6 | 13 | A |
3 | 50 | m | R | WF | 144 | 6 | 7 | 15 | ABD |
4 | 54 | f | L | CT | 132 | 5 | 6 | 13 | CD |
5 | 69 | m | L | WF | 84 | 2 | 2 | 7 | |
6 | 66 | f | L | O | 50 | 5 | 6 | 10 | ABD |
7 | 49 | m | L | O | 96 | 6 | 9 | 15 | ABCD |
8 | 82 | f | R | WF | 36 | 2 | 9 | 7 | |
9 | 21 | f | R | AR | 84 | 6 | 10 | 14 | BD |
10 | 66 | m | R | WF | 60 | 3 | 5 | 8 | ACD |
11 | 49 | f | L | RF | 36 | 2 | 10 | 9 | AC |
12 | 61 | f | R | CT | 96 | 7 | 8 | 10 | BCD |
13 | 43 | f | R | RF | 12 | 7 | 10 | 11 | ABCD |
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Thoma, P.; Drämel, N.; Grothe, M.; Lotze, M.; Fleischmann, R.; Strauss, S. Impaired Pain Processing at a Brainstem Level Is Involved in Maladaptive Neuroplasticity in Patients with Chronic Complex Regional Pain Syndrome. Int. J. Mol. Sci. 2022, 23, 15368. https://doi.org/10.3390/ijms232315368
Thoma P, Drämel N, Grothe M, Lotze M, Fleischmann R, Strauss S. Impaired Pain Processing at a Brainstem Level Is Involved in Maladaptive Neuroplasticity in Patients with Chronic Complex Regional Pain Syndrome. International Journal of Molecular Sciences. 2022; 23(23):15368. https://doi.org/10.3390/ijms232315368
Chicago/Turabian StyleThoma, Pauline, Nina Drämel, Matthias Grothe, Martin Lotze, Robert Fleischmann, and Sebastian Strauss. 2022. "Impaired Pain Processing at a Brainstem Level Is Involved in Maladaptive Neuroplasticity in Patients with Chronic Complex Regional Pain Syndrome" International Journal of Molecular Sciences 23, no. 23: 15368. https://doi.org/10.3390/ijms232315368