NSC Physiological Features in Spinal Muscular Atrophy: SMN Deficiency Effects on Neurogenesis
Abstract
:1. Neural Stem Cells
Induced Pluripotent Stem Cells (iPSCs) as NSC Precursors
2. Spinal Muscular Atrophy
SMN Isoforms
3. Physiological and Molecular Differences in Healthy and SMA NSCs
3.1. Epigenetic
3.2. SMN Protein Dosage and NSCs Properties
3.3. SMA, Mitochondria and NSCs
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Adami, R.; Bottai, D. NSC Physiological Features in Spinal Muscular Atrophy: SMN Deficiency Effects on Neurogenesis. Int. J. Mol. Sci. 2022, 23, 15209. https://doi.org/10.3390/ijms232315209
Adami R, Bottai D. NSC Physiological Features in Spinal Muscular Atrophy: SMN Deficiency Effects on Neurogenesis. International Journal of Molecular Sciences. 2022; 23(23):15209. https://doi.org/10.3390/ijms232315209
Chicago/Turabian StyleAdami, Raffaella, and Daniele Bottai. 2022. "NSC Physiological Features in Spinal Muscular Atrophy: SMN Deficiency Effects on Neurogenesis" International Journal of Molecular Sciences 23, no. 23: 15209. https://doi.org/10.3390/ijms232315209