Review Reports
- Raquel Griñán1,2,
- Joan Carles Escolà-Gil1,3 and
- Josep Julve1,3
- et al.
Reviewer 1: Eric De Groot Reviewer 2: Sobuj Mia
Round 1
Reviewer 1 Report
Thank you for allowing me to evaluate this well written paper on Hcy and (epi)genitcs.
I truly enjoyed the paper.
I have just one suggestion. The abstract ends without clear conclusions, where the text manuscript does. Please include these focussed conclusions in the abstract as well.
Very nice illustrations, otherwise I have no comments.
Author Response
Manuscript ID: ijms-1957522
Title: Epigenetic regulation by microRNAs in hyperhomocysteinemia-accelerated
atherosclerosis
Referee 1:
I have just one suggestion. The abstract ends without clear conclusions, where the text manuscript does. Please include these focussed conclusions in the abstract as well.
We thank the Reviewer for the encouraging and positive comments. We have revised the abstract following the Reviewer’s suggestions and added a conclusion with the examples of miRNAs that have been shown to play a key role in HHcy-related atherosclerosis (lines 41-49)
Reviewer 2 Report
This study has been designed and presented already in a way that easy to follow and understandable. However, Authors need to address some minor issues:
1) Need to discuss some aspects of fatty acid and glucose metabolism to connect how aberrant metabolic system contributes to atherosclerosis
2) Which enzymes or pathways of oxidative stress generation are involved in atherosclerotic complication need to discuss.
Author Response
Manuscript ID: ijms-1957522
Title: Epigenetic regulation by microRNAs in hyperhomocysteinemia-accelerated
atherosclerosis
Referee 2:
1) Need to discuss some aspects of fatty acid and glucose metabolism to connect how aberrant metabolic system contributes to atherosclerosis
2) Which enzymes or pathways of oxidative stress generation are involved in atherosclerotic complication need to discuss
We thank the Reviewer’s for the careful reading of the text and constructive suggestions.
We have revised the manuscript following the Reviewer’s suggestions as detailed below
We added and discussed this in lines 208-236
We added and discussed this in lines 257-272
We added new abbreviations from these new parts