Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Wang, Xingzhi; Tewari, Nitesh; Sato, Fuyuki; Tanimoto, Keiji; Thangavelu, Lakshmi; Makishima, Makoto; Bhawal, Ujjal K.

doi:10.3390/ijms23020962

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Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

by

Xingzhi Wang

^1,†

,

Nitesh Tewari

^2,†

,

Fuyuki Sato

³

,

Keiji Tanimoto

⁴

,

Lakshmi Thangavelu

⁵,

Makoto Makishima

^1,*

and

Ujjal K. Bhawal

^5,6,*

¹

Department of Biochemistry, Nihon University School of Medicine, Tokyo 173-8610, Japan

²

Centre for Dental Education and Research, Division of Pedodontics and Preventive Dentistry, All India Institute of Medical Sciences, New Delhi 110029, India

³

Shizuoka Cancer Center, Pathology Division, Shizuoka 411-8777, Japan

⁴

Department of Translational Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan

⁵

Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai 600077, India

⁶

Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan

^*

Authors to whom correspondence should be addressed.

^†

These authors are contributed equally to this work.

Int. J. Mol. Sci. 2022, 23(2), 962; https://doi.org/10.3390/ijms23020962

Submission received: 20 December 2021 / Revised: 12 January 2022 / Accepted: 13 January 2022 / Published: 16 January 2022

(This article belongs to the Special Issue Gene Expression and Molecular Targets of Oral Cancer and Periodontal Diseases)

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Abstract

Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help to optimize its use in clinical applications. Studies of NaF and epithelial cells, osteoblasts, osteoclasts, and periodontal cells have suggested the significant roles of fluoride treatment. In this review, we summarize recent studies on the biphasic functions of NaF that are related to both soft and hard periodontal tissues, multiple diseases, and clinical dentistry.

Keywords: fluoride; epithelial cells; mesenchymal stem cells; osteoblasts; osteoclasts; periodontal disease; miRNA

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MDPI and ACS Style

Wang, X.; Tewari, N.; Sato, F.; Tanimoto, K.; Thangavelu, L.; Makishima, M.; Bhawal, U.K. Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues. Int. J. Mol. Sci. 2022, 23, 962. https://doi.org/10.3390/ijms23020962

AMA Style

Wang X, Tewari N, Sato F, Tanimoto K, Thangavelu L, Makishima M, Bhawal UK. Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues. International Journal of Molecular Sciences. 2022; 23(2):962. https://doi.org/10.3390/ijms23020962

Chicago/Turabian Style

Wang, Xingzhi, Nitesh Tewari, Fuyuki Sato, Keiji Tanimoto, Lakshmi Thangavelu, Makoto Makishima, and Ujjal K. Bhawal. 2022. "Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues" International Journal of Molecular Sciences 23, no. 2: 962. https://doi.org/10.3390/ijms23020962

APA Style

Wang, X., Tewari, N., Sato, F., Tanimoto, K., Thangavelu, L., Makishima, M., & Bhawal, U. K. (2022). Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues. International Journal of Molecular Sciences, 23(2), 962. https://doi.org/10.3390/ijms23020962

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Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

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