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Review

Probing the Skin–Brain Axis: New Vistas Using Mouse Models

1
Institute of Anatomy, Otto-von-Guericke-University, Leipziger Str. 44, 39120 Magdeburg, Germany
2
Department of Dermatology, Otto-von-Guericke-University, Leipziger Str. 44, 39120 Magdeburg, Germany
3
Center for Behavioral Brain Sciences (CBBS), Universitätsplatz 2, 39106 Magdeburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Naoko Kanda
Int. J. Mol. Sci. 2022, 23(13), 7484; https://doi.org/10.3390/ijms23137484
Received: 8 June 2022 / Revised: 1 July 2022 / Accepted: 4 July 2022 / Published: 5 July 2022
(This article belongs to the Collection Feature Papers in Molecular Immunology)
Inflammatory diseases of the skin, including atopic dermatitis and psoriasis, have gained increasing attention with rising incidences in developed countries over the past decades. While bodily properties, such as immunological responses of the skin, have been described in some detail, interactions with the brain via different routes are less well studied. The suggested routes of the skin–brain axis comprise the immune system, HPA axis, and the peripheral and central nervous system, including microglia responses and structural changes. They provide starting points to investigate the molecular mechanisms of neuropsychiatric comorbidities in AD and psoriasis. To this end, mouse models exist for AD and psoriasis that could be tested for relevant behavioral entities. In this review, we provide an overview of the current mouse models and assays. By combining an extensive behavioral characterization and state-of-the-art genetic interventions with the investigation of underlying molecular pathways, insights into the mechanisms of the skin–brain axis in inflammatory cutaneous diseases are examined, which will spark further research in humans and drive the development of novel therapeutic strategies. View Full-Text
Keywords: atopic dermatitis; psoriasis; skin inflammation; skin–brain axis; HPA axis; cytokines atopic dermatitis; psoriasis; skin inflammation; skin–brain axis; HPA axis; cytokines
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MDPI and ACS Style

Weiglein, A.; Gaffal, E.; Albrecht, A. Probing the Skin–Brain Axis: New Vistas Using Mouse Models. Int. J. Mol. Sci. 2022, 23, 7484. https://doi.org/10.3390/ijms23137484

AMA Style

Weiglein A, Gaffal E, Albrecht A. Probing the Skin–Brain Axis: New Vistas Using Mouse Models. International Journal of Molecular Sciences. 2022; 23(13):7484. https://doi.org/10.3390/ijms23137484

Chicago/Turabian Style

Weiglein, Aliće, Evelyn Gaffal, and Anne Albrecht. 2022. "Probing the Skin–Brain Axis: New Vistas Using Mouse Models" International Journal of Molecular Sciences 23, no. 13: 7484. https://doi.org/10.3390/ijms23137484

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