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Article

The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses

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Preclinical Research Department, Labo’Life France, 1 Rue François Bruneau, 44000 Nantes, France
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ProfileHIT SASU, 7 Rue du Buisson, 44680 Sainte-Pazanne, France
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ArtImmune SAS, 13 Avenue Buffon, 45100 Orleans, France
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Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche 7355 (UMR7355), 3 B Rue de la Ferollerie, CEDEX 2, 45071 Orleans, France
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Experimental and Molecular Immunology and Neurogenetics, University of Orleans, Rue de la Ferollerie, CEDEX 2, 45100 Orleans, France
*
Author to whom correspondence should be addressed.
Academic Editor: Alexei Y. Bagrov
Int. J. Mol. Sci. 2022, 23(1), 110; https://doi.org/10.3390/ijms23010110
Received: 17 November 2021 / Revised: 20 December 2021 / Accepted: 21 December 2021 / Published: 22 December 2021
(This article belongs to the Section Molecular Pharmacology)
This study aimed at evaluating the effects of the micro-immunotherapy medicine (MIM) 2LEID, both in vitro and in vivo, on several components of the innate and adaptive immune system. MIM increased the phagocytic activity of macrophages, and it augmented the expression of the activation markers CD69 and HLA-DR in NK cells and monocytes/macrophages, respectively. The effect of MIM was evaluated in a model of respiratory infection induced by influenza A virus administration to immunocompetent mice in which it was able to improve neutrophil recruitment within the lungs (p = 0.1051) and slightly increased the circulating levels of IgM (p = 0.1655). Furthermore, MIM stimulated the proliferation of CD3-primed T lymphocytes and decreased the secretion of the immunosuppressive cytokine IL-10 in CD14+-derived macrophages. Human umbilical vein endothelial cells were finally used to explore the effect of MIM on endothelial cells, in which it slightly increased the expression of immune-related markers such as HLA-I, CD137L, GITRL, PD-L1 and ICAM-1. In conclusion, the present study suggests that MIM might be a promising nonspecific (without antigen specificity) immunostimulant drug in preventing and early treating respiratory infections, but not only exclusively, as it would gently support several facets of the immune system and host defenses. View Full-Text
Keywords: low dose; micro-immunotherapy; 2LEID, immunostimulant drug; respiratory infectious diseases; influenza A virus; host defenses; innate and adaptative immunity low dose; micro-immunotherapy; 2LEID, immunostimulant drug; respiratory infectious diseases; influenza A virus; host defenses; innate and adaptative immunity
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MDPI and ACS Style

Jacques, C.; Chatelais, M.; Fekir, K.; Fauconnier, L.; Mellier, M.; Togbe, D.; Floris, I. The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses. Int. J. Mol. Sci. 2022, 23, 110. https://doi.org/10.3390/ijms23010110

AMA Style

Jacques C, Chatelais M, Fekir K, Fauconnier L, Mellier M, Togbe D, Floris I. The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses. International Journal of Molecular Sciences. 2022; 23(1):110. https://doi.org/10.3390/ijms23010110

Chicago/Turabian Style

Jacques, Camille, Mathias Chatelais, Karim Fekir, Louis Fauconnier, Manon Mellier, Dieudonnée Togbe, and Ilaria Floris. 2022. "The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses" International Journal of Molecular Sciences 23, no. 1: 110. https://doi.org/10.3390/ijms23010110

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