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Date Palm Fruit (Phoenix dactylifera): Effects on Vascular Health and Future Research Directions

1
Department of Food and Nutrition Science, College of Health Sciences, Public Authority for Applied Education and Training, Shuwaikh 70654, Kuwait
2
Department of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
3
Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yun Jung Lee
Int. J. Mol. Sci. 2021, 22(9), 4665; https://doi.org/10.3390/ijms22094665
Received: 8 April 2021 / Revised: 26 April 2021 / Accepted: 27 April 2021 / Published: 28 April 2021
(This article belongs to the Special Issue The Beneficial Phytochemicals for Vascular Dysfunction)
Cardiovascular disease is a leading cause of death globally, presenting an immense public and economic burden. Studies on cardioprotective foods and their bioactive components are needed to address both personal and public health needs. Date fruit is rich in polyphenols, particularly flavonoids, certain micronutrients, and dietary fiber, which can impact vascular health, and have the potential to attenuate vascular disease in humans. Data from in vitro and animal studies report that consumption of date fruit or extracts can modulate select markers of vascular health, particularly plasma lipid levels including triglycerides and cholesterol, indices of oxidative stress and inflammation, but human data is scant. More investigation is needed to better characterize date polyphenols and unique bioactive compounds or fractions, establish safe and effective levels of intake, and delineate underlying mechanisms of action. Implementing scientific rigor in clinical trials and assessment of functional markers of vascular disease, such as flow-mediated dilation and peripheral arterial tonometry, along with gut microbiome profiles would provide useful information with respect to human health. Emerging data supports the notion that intake of date fruit and extracts can be a useful component of a healthy lifestyle for those seeking beneficial effects on vascular health. View Full-Text
Keywords: polyphenols; flavonoids; cardiovascular; inflammation; lipids; oxidative stress; endothelial function polyphenols; flavonoids; cardiovascular; inflammation; lipids; oxidative stress; endothelial function
MDPI and ACS Style

Al-Dashti, Y.A.; Holt, R.R.; Keen, C.L.; Hackman, R.M. Date Palm Fruit (Phoenix dactylifera): Effects on Vascular Health and Future Research Directions. Int. J. Mol. Sci. 2021, 22, 4665. https://doi.org/10.3390/ijms22094665

AMA Style

Al-Dashti YA, Holt RR, Keen CL, Hackman RM. Date Palm Fruit (Phoenix dactylifera): Effects on Vascular Health and Future Research Directions. International Journal of Molecular Sciences. 2021; 22(9):4665. https://doi.org/10.3390/ijms22094665

Chicago/Turabian Style

Al-Dashti, Yousef A., Roberta R. Holt, Carl L. Keen, and Robert M. Hackman 2021. "Date Palm Fruit (Phoenix dactylifera): Effects on Vascular Health and Future Research Directions" International Journal of Molecular Sciences 22, no. 9: 4665. https://doi.org/10.3390/ijms22094665

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