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Review

pCTX-M3—Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland
Academic Editors: Baltasar Mayo and Ana Belén Flórez
Int. J. Mol. Sci. 2021, 22(9), 4606; https://doi.org/10.3390/ijms22094606
Received: 7 April 2021 / Revised: 23 April 2021 / Accepted: 26 April 2021 / Published: 27 April 2021
(This article belongs to the Special Issue Antibiotic Resistance: Appearance, Evolution, and Spread)
pCTX-M3 is the archetypic member of the IncM incompatibility group of conjugative plasmids (recently referred to as IncM2). It is responsible for the worldwide dissemination of numerous antibiotic resistance genes, including those coding for extended-spectrum β-lactamases and conferring resistance to aminoglycosides. The IncM plasmids acquired during evolution diverse mobile genetic elements found in one or two multiple resistance regions, MRR(s), grouping antibiotic resistance genes as well as mobile genetic elements or their remnants. The IncM plasmids can be found in bacteria inhabiting various environments. The information on the structure and biology of pCTX-M3 is integrated in this review. It focuses on the functional modules of pCTX-M3 responsible for its replication, stable maintenance, and conjugative transfer, indicating that the host range of the pCTX-M3 replicon is limited to representatives of the family Enterobacteriaceae (Enterobacterales ord. nov.), while the range of recipients of its conjugation system is wide, comprising Alpha-, Beta-, and Gammaproteobacteria, and also Firmicutes. View Full-Text
Keywords: plasmid; IncM; blaCTX-M-3; conjugative transfer; antibiotic resistance plasmid; IncM; blaCTX-M-3; conjugative transfer; antibiotic resistance
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MDPI and ACS Style

Kern-Zdanowicz, I. pCTX-M3—Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range. Int. J. Mol. Sci. 2021, 22, 4606. https://doi.org/10.3390/ijms22094606

AMA Style

Kern-Zdanowicz I. pCTX-M3—Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range. International Journal of Molecular Sciences. 2021; 22(9):4606. https://doi.org/10.3390/ijms22094606

Chicago/Turabian Style

Kern-Zdanowicz, Izabela. 2021. "pCTX-M3—Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range" International Journal of Molecular Sciences 22, no. 9: 4606. https://doi.org/10.3390/ijms22094606

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