Regulatory Light Chains in Cardiac Development and Disease
Abstract
:1. Introduction
2. Structure of Regulatory Light Chains
3. Regulatory Light Chains in Cardiac Development
4. The Role of Regulatory Light Chains in Normal and Diseased Hearts
5. Experimental Strategies to Study and Exploit the Use of Regulatory Light Chains
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Species | Normal Ventricles (mol Pi/mol RLC) | Diseased Ventricles (mol Pi/mol RLC) | References |
---|---|---|---|
Human | 0.39–0.40 | 0–0.6 (End-stage heart failure) | [1,72] |
Pigs | 0.39 | Decrease (Ischaemic failing heart model) | [72,89] |
Rat | 0.39 | 0.76 (Ischaemic failing heart model) Decrease (Ischaemic failing heart model) | [1,72,90] |
Rabbit | 0.36 | – | [72] |
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Markandran, K.; Poh, J.W.; Ferenczi, M.A.; Cheung, C. Regulatory Light Chains in Cardiac Development and Disease. Int. J. Mol. Sci. 2021, 22, 4351. https://doi.org/10.3390/ijms22094351
Markandran K, Poh JW, Ferenczi MA, Cheung C. Regulatory Light Chains in Cardiac Development and Disease. International Journal of Molecular Sciences. 2021; 22(9):4351. https://doi.org/10.3390/ijms22094351
Chicago/Turabian StyleMarkandran, Kasturi, Jane Wenjin Poh, Michael A. Ferenczi, and Christine Cheung. 2021. "Regulatory Light Chains in Cardiac Development and Disease" International Journal of Molecular Sciences 22, no. 9: 4351. https://doi.org/10.3390/ijms22094351