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JNK Pathway in CNS Pathologies

Instituto Cajal (CSIC), Av. Doctor Arce 37, 28002 Madrid, Spain
Author to whom correspondence should be addressed.
These authors are equal contribution.
Academic Editor: Carme Auladell
Int. J. Mol. Sci. 2021, 22(8), 3883;
Received: 21 February 2021 / Revised: 30 March 2021 / Accepted: 1 April 2021 / Published: 9 April 2021
(This article belongs to the Special Issue Function and Mechanisms of JNK Pathway)
The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide range of internal and external cellular stress signals. Beside the stress response, the JNK pathway is involved in a series of vital regulatory mechanisms during development and adulthood that are critical to maintain tissue homeostasis. These mechanisms include the regulation of apoptosis, growth, proliferation, differentiation, migration and invasion. The JNK pathway has a diverse functionality and cell-tissue specificity, and has emerged as a key player in regeneration, tumorigenesis and other pathologies. The JNK pathway is highly active in the central nervous system (CNS), and plays a central role when cells need to cope with pathophysiological insults during development and adulthood. Here, we review the implications of the JNK pathway in pathologies of the CNS. More specifically, we discuss some newly identified examples and mechanisms of JNK-driven tumor progression in glioblastoma, regeneration/repair after an injury, neurodegeneration and neuronal cell death. All these new discoveries support the central role of JNK in CNS pathologies and reinforce the idea of JNK as potential target to reduce their detrimental effects. View Full-Text
Keywords: MAP kinase; cell signalling; glioblastoma; neurodegenerative disorders; CNS injuries MAP kinase; cell signalling; glioblastoma; neurodegenerative disorders; CNS injuries
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MDPI and ACS Style

de los Reyes Corrales, T.; Losada-Pérez, M.; Casas-Tintó, S. JNK Pathway in CNS Pathologies. Int. J. Mol. Sci. 2021, 22, 3883.

AMA Style

de los Reyes Corrales T, Losada-Pérez M, Casas-Tintó S. JNK Pathway in CNS Pathologies. International Journal of Molecular Sciences. 2021; 22(8):3883.

Chicago/Turabian Style

de los Reyes Corrales, Teresa, María Losada-Pérez, and Sergio Casas-Tintó. 2021. "JNK Pathway in CNS Pathologies" International Journal of Molecular Sciences 22, no. 8: 3883.

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