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Review

miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies

1
Agriculture and Agri-Food Canada, Sherbrooke Research and Development Centre, Sherbrooke, QC J1M 0C8, Canada
2
Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam
3
Advanced Milk Testing Research Laboratory, Postgraduate Institute of Veterinary Education and Research, Institute of Veterinary Education and Research (RAJUVAS), Jaipur 302001, Rajasthan, India
4
Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, Rajasthan, India
5
Department of Animal Science, McGill University, Ste-Anne-de Bellevue, QC H9X 3V9, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Bo-Young Lee and Siriluck Ponsuksili
Int. J. Mol. Sci. 2021, 22(6), 3080; https://doi.org/10.3390/ijms22063080
Received: 29 December 2020 / Revised: 3 March 2021 / Accepted: 8 March 2021 / Published: 17 March 2021
(This article belongs to the Special Issue microRNA Regulatory Network)
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression post-transcriptionally by targeting either the 3′ untranslated or coding regions of genes. They have been reported to play key roles in a wide range of biological processes. The recent remarkable developments of transcriptomics technologies, especially next-generation sequencing technologies and advanced bioinformatics tools, allow more in-depth exploration of messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs), including miRNAs. These technologies have offered great opportunities for a deeper exploration of miRNA involvement in farm animal diseases, as well as livestock productivity and welfare. In this review, we provide an overview of the current knowledge of miRNA roles in major farm animal diseases with a particular focus on diseases of economic importance. In addition, we discuss the steps and future perspectives of using miRNAs as biomarkers and molecular therapy for livestock disease management as well as the challenges and opportunities for understanding the regulatory mechanisms of miRNAs related to disease pathogenesis. View Full-Text
Keywords: livestock diseases; miRNAs; biomarkers; regulatory networks; mastitis; PRRSV; foot-and-mouth disease; Marek’s disease; RNAi therapy livestock diseases; miRNAs; biomarkers; regulatory networks; mastitis; PRRSV; foot-and-mouth disease; Marek’s disease; RNAi therapy
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MDPI and ACS Style

Do, D.N.; Dudemaine, P.-L.; Mathur, M.; Suravajhala, P.; Zhao, X.; Ibeagha-Awemu, E.M. miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies. Int. J. Mol. Sci. 2021, 22, 3080. https://doi.org/10.3390/ijms22063080

AMA Style

Do DN, Dudemaine P-L, Mathur M, Suravajhala P, Zhao X, Ibeagha-Awemu EM. miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies. International Journal of Molecular Sciences. 2021; 22(6):3080. https://doi.org/10.3390/ijms22063080

Chicago/Turabian Style

Do, Duy N., Pier-Luc Dudemaine, Manisha Mathur, Prashanth Suravajhala, Xin Zhao, and Eveline M. Ibeagha-Awemu 2021. "miRNA Regulatory Functions in Farm Animal Diseases, and Biomarker Potentials for Effective Therapies" International Journal of Molecular Sciences 22, no. 6: 3080. https://doi.org/10.3390/ijms22063080

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