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Specialized Pro-Resolving Mediators and the Lymphatic System

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Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden
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Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 40530 Gothenburg, Sweden
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Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Faculty of Medicine and Health Sciences, Linköping University, 58185 Linköping, Sweden
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Department of Experimental Medical Science, Lund University, 22100 Lund, Sweden
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Wallenberg Centre for Molecular Medicine, Lund University, 22100 Lund, Sweden
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Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden
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Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
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Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201, USA
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Region Vaestra Goetaland, Department of Clinical Physiology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Academic Editors: Sinem Karaman, Maike Frye and Katarzyna Koltowska
Int. J. Mol. Sci. 2021, 22(5), 2750; https://doi.org/10.3390/ijms22052750
Received: 30 January 2021 / Revised: 26 February 2021 / Accepted: 4 March 2021 / Published: 9 March 2021
Diminished lymphatic function and abnormal morphology are common in chronic inflammatory diseases. Recent studies are investigating whether it is possible to target chronic inflammation by promoting resolution of inflammation, in order to enhance lymphatic function and attenuate disease. Resolution of inflammation is an active process regulated by bioactive lipids known as specialized pro-resolving mediators (SPMs). SPMs can modulate leukocyte migration and function, alter cytokine/chemokine release, modify autophagy, among other immune-related activities. Here, we summarize the role of the lymphatics in resolution of inflammation and lymphatic impairment in chronic inflammatory diseases. Furthermore, we discuss the current literature describing the connection between SPMs and the lymphatics, and the possibility of targeting the lymphatics with innovative SPM therapy to promote resolution of inflammation and mitigate disease. View Full-Text
Keywords: specialized pro-resolving mediators (SPMs); lymphatics; resolution of inflammation; lymphoid organs; atherosclerosis; inflammatory bowel disease; dry eye disease specialized pro-resolving mediators (SPMs); lymphatics; resolution of inflammation; lymphoid organs; atherosclerosis; inflammatory bowel disease; dry eye disease
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MDPI and ACS Style

Kraft, J.D.; Blomgran, R.; Lundgaard, I.; Quiding-Järbrink, M.; Bromberg, J.S.; Börgeson, E. Specialized Pro-Resolving Mediators and the Lymphatic System. Int. J. Mol. Sci. 2021, 22, 2750. https://doi.org/10.3390/ijms22052750

AMA Style

Kraft JD, Blomgran R, Lundgaard I, Quiding-Järbrink M, Bromberg JS, Börgeson E. Specialized Pro-Resolving Mediators and the Lymphatic System. International Journal of Molecular Sciences. 2021; 22(5):2750. https://doi.org/10.3390/ijms22052750

Chicago/Turabian Style

Kraft, Jamie D.; Blomgran, Robert; Lundgaard, Iben; Quiding-Järbrink, Marianne; Bromberg, Jonathan S.; Börgeson, Emma. 2021. "Specialized Pro-Resolving Mediators and the Lymphatic System" Int. J. Mol. Sci. 22, no. 5: 2750. https://doi.org/10.3390/ijms22052750

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