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Review

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

1
Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405, USA
2
The University of Vermont Cancer Center, University of Vermont, Burlington, VT 05405, USA
3
Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA
4
Department of Pediatrics, University of Vermont, Burlington, VT 05405, USA
5
Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Simona Soverini
Int. J. Mol. Sci. 2021, 22(5), 2683; https://doi.org/10.3390/ijms22052683
Received: 16 February 2021 / Revised: 1 March 2021 / Accepted: 3 March 2021 / Published: 7 March 2021
(This article belongs to the Special Issue Advances in Molecular Biology and Targeted Therapy of Leukemias 3.0)
Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell acute lymphoblastic leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL. View Full-Text
Keywords: non-coding; leukemia; B-cell; RNA-sequencing; small RNA-sequencing non-coding; leukemia; B-cell; RNA-sequencing; small RNA-sequencing
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MDPI and ACS Style

Rodriguez, P.D.; Paculova, H.; Kogut, S.; Heath, J.; Schjerven, H.; Frietze, S. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. Int. J. Mol. Sci. 2021, 22, 2683. https://doi.org/10.3390/ijms22052683

AMA Style

Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S. Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences. 2021; 22(5):2683. https://doi.org/10.3390/ijms22052683

Chicago/Turabian Style

Rodriguez, Princess D., Hana Paculova, Sophie Kogut, Jessica Heath, Hilde Schjerven, and Seth Frietze. 2021. "Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia" International Journal of Molecular Sciences 22, no. 5: 2683. https://doi.org/10.3390/ijms22052683

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