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Article

Influence of Antiplatelet Agents on the Lipid Composition of Platelet Plasma Membrane: A Lipidomics Approach with Ticagrelor and Its Active Metabolite

1
EA 3920, Université Bourgogne Franche-Comté, F-25000 Besançon, France
2
Laboratoire de Pharmacologie Clinique et Toxicologie-CHU de Besançon, F-25000 Besançon, France
3
Laboratoire Chrono Environnement UMR CNRS 6249, Université de Bourgogne Franche-Comté, 16 Route de Gray, CEDEX, 25030 Besançon, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Ilya Nikolaevich Medvedev
Int. J. Mol. Sci. 2021, 22(3), 1432; https://doi.org/10.3390/ijms22031432
Received: 28 November 2020 / Revised: 21 January 2021 / Accepted: 23 January 2021 / Published: 31 January 2021
(This article belongs to the Special Issue Physiology of Platelets in Humans and Animals)
Lipids contained in the plasma membrane of platelets play an important role in platelet function. Modifications in the lipid composition can fluidify or rigidify the environment around embedded receptors, in order to facilitate the access of the receptor by the drug. However, data concerning the lipid composition of platelet plasma membrane need to be updated. In addition, data on the impact of drugs on plasma membrane composition, in particular antiplatelet agents, remain sparse. After isolation of platelet plasma membrane, we assessed, using lipidomics, the effect of ticagrelor, a P2Y12 antagonist, and its active metabolite on the lipid composition of these plasma membranes. We describe the exact lipid composition of plasma membrane, including all sub-species. Ticagrelor and its active metabolite significantly increased cholesterol and phosphatidylcholine ether with short saturated acyl chains 16:0/16:0, and decreased phosphatidylcholine, suggesting overall rigidification of the membrane. Furthermore, ticagrelor and its active metabolite decreased some arachidonylated plasmalogens, suggesting a decrease in availability of arachidonic acid from the membrane phospholipids for synthesis of biologically active mediators. To conclude, ticagrelor and its active metabolite seem to influence the lipid environment of receptors embedded in the lipid bilayer and modify the behavior of the plasma membrane. View Full-Text
Keywords: lipidomics; platelets; plasma membrane; lipids; receptor; ticagrelor lipidomics; platelets; plasma membrane; lipids; receptor; ticagrelor
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MDPI and ACS Style

Lagoutte-Renosi, J.; Allemand, F.; Ramseyer, C.; Rabani, V.; Davani, S. Influence of Antiplatelet Agents on the Lipid Composition of Platelet Plasma Membrane: A Lipidomics Approach with Ticagrelor and Its Active Metabolite. Int. J. Mol. Sci. 2021, 22, 1432. https://doi.org/10.3390/ijms22031432

AMA Style

Lagoutte-Renosi J, Allemand F, Ramseyer C, Rabani V, Davani S. Influence of Antiplatelet Agents on the Lipid Composition of Platelet Plasma Membrane: A Lipidomics Approach with Ticagrelor and Its Active Metabolite. International Journal of Molecular Sciences. 2021; 22(3):1432. https://doi.org/10.3390/ijms22031432

Chicago/Turabian Style

Lagoutte-Renosi, Jennifer, Florentin Allemand, Christophe Ramseyer, Vahideh Rabani, and Siamak Davani. 2021. "Influence of Antiplatelet Agents on the Lipid Composition of Platelet Plasma Membrane: A Lipidomics Approach with Ticagrelor and Its Active Metabolite" International Journal of Molecular Sciences 22, no. 3: 1432. https://doi.org/10.3390/ijms22031432

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