Next Article in Journal
Expression of Recombinant Human Octamer-Binding Transcription Factor 4 in Rice Suspension Cells
Next Article in Special Issue
Accelerated Wound Closure of Deep Partial Thickness Burns with Acellular Fish Skin Graft
Previous Article in Journal
lncRNA CASC19 Contributes to Radioresistance of Nasopharyngeal Carcinoma by Promoting Autophagy via AMPK-mTOR Pathway
Previous Article in Special Issue
Ibudilast Mitigates Delayed Bone Healing Caused by Lipopolysaccharide by Altering Osteoblast and Osteoclast Activity
 
 
Review

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

1
National Laboratory of Nanotechnology (LANOTEC), National Center for High Technology (CeNAT), 1174-1200 San José, Costa Rica
2
Physical Chemistry Laboratory, Faculty of Pharmacy, University of Costa Rica, 11501-2060 San José, Costa Rica
3
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Costa Rica, 11501-2060 San José, Costa Rica
4
Nuclear Research Center, Faculty of Science, Universidad de la República (UdelaR), 11300 Montevideo, Uruguay
5
Laboratory of Polymers (POLIUNA), Chemistry School, National University of Costa Rica, 86-3000 Heredia, Costa Rica
*
Author to whom correspondence should be addressed.
Academic Editor: John G. Hardy
Int. J. Mol. Sci. 2021, 22(3), 1408; https://doi.org/10.3390/ijms22031408
Received: 1 December 2020 / Revised: 13 January 2021 / Accepted: 27 January 2021 / Published: 30 January 2021
(This article belongs to the Special Issue Advanced Biomaterials for Wound Healing 2021)
Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects. View Full-Text
Keywords: critical solution temperature; inflammation; nanomedicine; smart polymers; tissue engineering critical solution temperature; inflammation; nanomedicine; smart polymers; tissue engineering
Show Figures

Figure 1

MDPI and ACS Style

Castillo-Henríquez, L.; Castro-Alpízar, J.; Lopretti-Correa, M.; Vega-Baudrit, J. Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing. Int. J. Mol. Sci. 2021, 22, 1408. https://doi.org/10.3390/ijms22031408

AMA Style

Castillo-Henríquez L, Castro-Alpízar J, Lopretti-Correa M, Vega-Baudrit J. Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing. International Journal of Molecular Sciences. 2021; 22(3):1408. https://doi.org/10.3390/ijms22031408

Chicago/Turabian Style

Castillo-Henríquez, Luis, Jose Castro-Alpízar, Mary Lopretti-Correa, and José Vega-Baudrit. 2021. "Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing" International Journal of Molecular Sciences 22, no. 3: 1408. https://doi.org/10.3390/ijms22031408

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop