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Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?
Review

Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK
Academic Editor: L. K. Ong
Int. J. Mol. Sci. 2021, 22(24), 13442; https://doi.org/10.3390/ijms222413442
Received: 16 November 2021 / Revised: 9 December 2021 / Accepted: 10 December 2021 / Published: 14 December 2021
After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of neurons both in brain areas surrounding the infarct, known as ‘selective neuronal loss’, and in brain areas remote from, but connected to, the infarct, known as ‘secondary neurodegeneration’. Here we review evidence indicating that this delayed loss of neurons after stroke is mediated by the microglial phagocytosis of stressed neurons. After a stroke, neurons are stressed by ongoing ischemia, excitotoxicity and/or inflammation and are known to: (i) release “find-me” signals such as ATP, (ii) expose “eat-me” signals such as phosphatidylserine, and (iii) bind to opsonins, such as complement components C1q and C3b, inducing microglia to phagocytose such neurons. Blocking these factors on neurons, or their phagocytic receptors on microglia, can prevent delayed neuronal loss and behavioral deficits in rodent models of ischemic stroke. Phagocytic receptors on microglia may be attractive treatment targets to prevent delayed neuronal loss after stroke due to the microglial phagocytosis of stressed neurons. View Full-Text
Keywords: stroke; cell death; neuronal death; delayed neuronal death; selective neuronal loss; secondary neurodegeneration; phagocytosis; microglia; phagoptosis; ischemia stroke; cell death; neuronal death; delayed neuronal death; selective neuronal loss; secondary neurodegeneration; phagocytosis; microglia; phagoptosis; ischemia
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MDPI and ACS Style

Brown, G.C. Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons. Int. J. Mol. Sci. 2021, 22, 13442. https://doi.org/10.3390/ijms222413442

AMA Style

Brown GC. Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons. International Journal of Molecular Sciences. 2021; 22(24):13442. https://doi.org/10.3390/ijms222413442

Chicago/Turabian Style

Brown, Guy C. 2021. "Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons" International Journal of Molecular Sciences 22, no. 24: 13442. https://doi.org/10.3390/ijms222413442

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