Albumin–Hyaluronan Interactions: Influence of Ionic Composition Probed by Molecular Dynamics
Abstract
:1. Introduction
2. Results and Discussion
3. Methods
3.1. Binding Energy Calculation
3.2. Hydrogen Bond Characteristics Determination
3.3. Water Bridges
3.4. Ionic Interactions
3.5. Hydrophobic Interactions
- −
- carbons carrying three hydrogen atoms,
- −
- carbon carrying two hydrogen atoms or carbon with one hydrogen and three carbon atoms attached,
- −
- carbons forming an aromatic ring carrying hydrogen atoms.
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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HSA–Hyaluronan Complex Number 1 | HSA Binding Domains |
---|---|
1(2) | IA-IB-IIIA-IIIB |
2(7) | IA-IIIA-IIIB |
3(10) | IA-IIIA-IIIB |
4(1) | IA-IB-IIIA-IIIB |
5(5) | IIIA-IIIB |
6(3) | IA-IIIA-IIIB |
7(9) | IA-IIIA-IIIB |
8(11) | IIIA-IIIB |
9(12) | IIB-IIIA-IIIB |
10(6) | IA-IIIA-IIIB |
11(8) | IIIA-IIIB |
12(4) | IIIA-IIIB |
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Bełdowski, P.; Przybyłek, M.; Raczyński, P.; Dedinaite, A.; Górny, K.; Wieland, F.; Dendzik, Z.; Sionkowska, A.; Claesson, P.M. Albumin–Hyaluronan Interactions: Influence of Ionic Composition Probed by Molecular Dynamics. Int. J. Mol. Sci. 2021, 22, 12360. https://doi.org/10.3390/ijms222212360
Bełdowski P, Przybyłek M, Raczyński P, Dedinaite A, Górny K, Wieland F, Dendzik Z, Sionkowska A, Claesson PM. Albumin–Hyaluronan Interactions: Influence of Ionic Composition Probed by Molecular Dynamics. International Journal of Molecular Sciences. 2021; 22(22):12360. https://doi.org/10.3390/ijms222212360
Chicago/Turabian StyleBełdowski, Piotr, Maciej Przybyłek, Przemysław Raczyński, Andra Dedinaite, Krzysztof Górny, Florian Wieland, Zbigniew Dendzik, Alina Sionkowska, and Per M. Claesson. 2021. "Albumin–Hyaluronan Interactions: Influence of Ionic Composition Probed by Molecular Dynamics" International Journal of Molecular Sciences 22, no. 22: 12360. https://doi.org/10.3390/ijms222212360