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Review

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

1
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India
2
Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 50A Doświadczalna Street, 20-280 Lublin, Poland
3
Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
4
Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia
5
Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia
6
Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Kwang-Hyun Baek and Giuseppe Servillo
Int. J. Mol. Sci. 2021, 22(21), 11971; https://doi.org/10.3390/ijms222111971
Received: 27 September 2021 / Revised: 27 October 2021 / Accepted: 28 October 2021 / Published: 4 November 2021
(This article belongs to the Special Issue Ubiquitin and Ubiquitin-Like Molecules in Cancer)
The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is widely known for its role in degrading abnormal protein substrates and maintaining physiological body functions via ubiquitinating enzymes (E1, E2, E3) and the proteasome. Therefore, aberrant expression in these enzymes results in an altered biological process, including transduction signaling for cell death and survival, resulting in cancer. In this review, an overview of profuse enzymes involved as a pro-oncogenic or progressive growth factor in tumors with their downstream signaling pathways has been discussed. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was carried out to understand the nature of the extensive work done on modulation of ubiquitin-proteasome pathways in oncogenic signaling. Various in vitro, in vivo studies demonstrating the involvement of ubiquitin-proteasome systems in varied types of cancers and the downstream signaling pathways involved are also discussed in the current review. Several inhibitors of E1, E2, E3, deubiquitinase enzymes and proteasome have been applied for treating cancer. Some of these drugs have exhibited successful outcomes in in vivo studies on different cancer types, so clinical trials are going on for these inhibitors. This review mainly focuses on certain ubiquitin-proteasome enzymes involved in developing cancers and certain enzymes that can be targeted to treat cancer. View Full-Text
Keywords: cancer; ubiquitination; ubiquitin-proteasome system; deubiquitination; ubiquitin inhibitors cancer; ubiquitination; ubiquitin-proteasome system; deubiquitination; ubiquitin inhibitors
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MDPI and ACS Style

Sharma, A.; Khan, H.; Singh, T.G.; Grewal, A.K.; Najda, A.; Kawecka-Radomska, M.; Kamel, M.; Altyar, A.E.; Abdel-Daim, M.M. Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling. Int. J. Mol. Sci. 2021, 22, 11971. https://doi.org/10.3390/ijms222111971

AMA Style

Sharma A, Khan H, Singh TG, Grewal AK, Najda A, Kawecka-Radomska M, Kamel M, Altyar AE, Abdel-Daim MM. Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling. International Journal of Molecular Sciences. 2021; 22(21):11971. https://doi.org/10.3390/ijms222111971

Chicago/Turabian Style

Sharma, Anmol, Heena Khan, Thakur G. Singh, Amarjot K. Grewal, Agnieszka Najda, Małgorzata Kawecka-Radomska, Mohamed Kamel, Ahmed E. Altyar, and Mohamed M. Abdel-Daim. 2021. "Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling" International Journal of Molecular Sciences 22, no. 21: 11971. https://doi.org/10.3390/ijms222111971

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