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Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
Review

Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies

1
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, McMaster University, Hamilton, ON L8S 4L8, Canada
2
College of Medicine and Health, University College Cork, T12 XF62 Cork, Ireland
3
Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
4
School of Medicine, Royal College of Surgeons in Ireland, D02 YN77 Dublin, Ireland
5
Department of Pediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada
6
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Annemarie Boleij
Int. J. Mol. Sci. 2021, 22(21), 11365; https://doi.org/10.3390/ijms222111365
Received: 7 September 2021 / Revised: 2 October 2021 / Accepted: 5 October 2021 / Published: 21 October 2021
(This article belongs to the Special Issue Host-Microbe Interactions in Ulcerative Colitis)
Ulcerative colitis (UC) is a chronic autoimmune disorder affecting the colonic mucosa. UC is a subtype of inflammatory bowel disease along with Crohn’s disease and presents with varying extraintestinal manifestations. No single etiology for UC has been found, but a combination of genetic and environmental factors is suspected. Research has focused on the role of intestinal dysbiosis in the pathogenesis of UC, including the effects of dysbiosis on the integrity of the colonic mucosal barrier, priming and regulation of the host immune system, chronic inflammation, and progression to tumorigenesis. Characterization of key microbial taxa and their implications in the pathogenesis of UC and colitis-associated cancer (CAC) may present opportunities for modulating intestinal inflammation through microbial-targeted therapies. In this review, we discuss the microbiota-immune crosstalk in UC and CAC, as well as the evolution of microbiota-based therapies. View Full-Text
Keywords: ulcerative colitis; inflammatory bowel diseases; pediatrics; FMT; probiotics; synbiotics; antibiotics; prebiotics; fecal microbiota transplant; colitis-associated cancer; colorectal cancer; CAC; CRC; dysbiosis ulcerative colitis; inflammatory bowel diseases; pediatrics; FMT; probiotics; synbiotics; antibiotics; prebiotics; fecal microbiota transplant; colitis-associated cancer; colorectal cancer; CAC; CRC; dysbiosis
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MDPI and ACS Style

Popov, J.; Caputi, V.; Nandeesha, N.; Rodriguez, D.A.; Pai, N. Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies. Int. J. Mol. Sci. 2021, 22, 11365. https://doi.org/10.3390/ijms222111365

AMA Style

Popov J, Caputi V, Nandeesha N, Rodriguez DA, Pai N. Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies. International Journal of Molecular Sciences. 2021; 22(21):11365. https://doi.org/10.3390/ijms222111365

Chicago/Turabian Style

Popov, Jelena, Valentina Caputi, Nandini Nandeesha, David A. Rodriguez, and Nikhil Pai. 2021. "Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies" International Journal of Molecular Sciences 22, no. 21: 11365. https://doi.org/10.3390/ijms222111365

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