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Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives

1
Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
2
Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Muneyoshi Okada
Int. J. Mol. Sci. 2021, 22(2), 913; https://doi.org/10.3390/ijms22020913
Received: 16 December 2020 / Revised: 12 January 2021 / Accepted: 13 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Extracellular Matrix in Heart Disease 2.0)
Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in developed countries and in the ageing population. It is strongly correlated to median age, affecting up to 13% of the population over the age of 65. Pathophysiological analysis indicates CAVD as a result of an active and degenerative disease, starting with sclerosis and chronic inflammation and then leaflet calcification, which ultimately can account for aortic stenosis. Although CAVD has been firstly recognized as a passive event mostly resulting from a degenerative aging process, much evidences suggests that calcification arises from different active processes, involving both aortic valve-resident cells (valve endothelial cells, valve interstitial cells, mesenchymal stem cells, innate immunity cells) and circulating cells (circulating mesenchymal cells, immunity cells). Moreover, a role for the cell-derived “matrix vesicles” and extracellular matrix (ECM) components has also been recognized. The aim of this work is to review the cellular and molecular alterations occurring in aortic valve during CAVD pathogenesis, focusing on the role of ECM in the natural course of the disease. View Full-Text
Keywords: calcific aortic valve disease; extracellular matrix; extracellular vesicles; collagen; elastic fibers; tenascin-C; periostin calcific aortic valve disease; extracellular matrix; extracellular vesicles; collagen; elastic fibers; tenascin-C; periostin
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MDPI and ACS Style

Di Vito, A.; Donato, A.; Presta, I.; Mancuso, T.; Brunetti, F.S.; Mastroroberto, P.; Amorosi, A.; Malara, N.; Donato, G. Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives. Int. J. Mol. Sci. 2021, 22, 913. https://doi.org/10.3390/ijms22020913

AMA Style

Di Vito A, Donato A, Presta I, Mancuso T, Brunetti FS, Mastroroberto P, Amorosi A, Malara N, Donato G. Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives. International Journal of Molecular Sciences. 2021; 22(2):913. https://doi.org/10.3390/ijms22020913

Chicago/Turabian Style

Di Vito, Anna, Annalidia Donato, Ivan Presta, Teresa Mancuso, Francesco S. Brunetti, Pasquale Mastroroberto, Andrea Amorosi, Natalia Malara, and Giuseppe Donato. 2021. "Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives" International Journal of Molecular Sciences 22, no. 2: 913. https://doi.org/10.3390/ijms22020913

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