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Review

Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment

1
Department of Pharmacognosy, Poznan University of Medical Sciences, Swiecickiego 4, 61-781 Poznan, Poland
2
Department of Pharmacognosy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Cracow, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 778; https://doi.org/10.3390/ijms22020778
Received: 29 November 2020 / Revised: 30 December 2020 / Accepted: 11 January 2021 / Published: 14 January 2021
Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of Cannabis (in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19)), which has been proven so far, results from the affinity of these compounds predominantly for the receptors of the endocannabinoid system (the cannabinoid receptor type 1 (CB1), type two (CB2), and the G protein-coupled receptor 55 (GPR55)) but, also, for peroxisome proliferator-activated receptor (PPAR), glycine receptors, serotonin receptors (5-HT), transient receptor potential channels (TRP), and GPR, opioid receptors. The synergism of action of phytochemicals present in Cannabis sp. raw material is also expressed in their increased bioavailability and penetration through the blood–brain barrier. This review provides an overview of phytochemistry and pharmacology of compounds present in Cannabis extracts in the context of the current knowledge about their synergistic actions and the implications of clinical use in the treatment of selected diseases. View Full-Text
Keywords: Cannabis; phytocannabinoids (THC and CBD); terpenes; multitarget; receptors Cannabis; phytocannabinoids (THC and CBD); terpenes; multitarget; receptors
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MDPI and ACS Style

Stasiłowicz, A.; Tomala, A.; Podolak, I.; Cielecka-Piontek, J. Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment. Int. J. Mol. Sci. 2021, 22, 778. https://doi.org/10.3390/ijms22020778

AMA Style

Stasiłowicz A, Tomala A, Podolak I, Cielecka-Piontek J. Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment. International Journal of Molecular Sciences. 2021; 22(2):778. https://doi.org/10.3390/ijms22020778

Chicago/Turabian Style

Stasiłowicz, Anna, Anna Tomala, Irma Podolak, and Judyta Cielecka-Piontek. 2021. "Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment" International Journal of Molecular Sciences 22, no. 2: 778. https://doi.org/10.3390/ijms22020778

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