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Volume 22
Issue 19
10.3390/ijms221910233
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Review
Peer-Review Record

Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine

Int. J. Mol. Sci. 2021, 22(19), 10233; https://doi.org/10.3390/ijms221910233
by Jingqi Qi 1,2, Tianqi Yu 3, Bangyan Hu 4, Hongwei Wu 1,2,* and Hongwei Ouyang 1,2,5,6,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(19), 10233; https://doi.org/10.3390/ijms221910233
Submission received: 31 August 2021 / Revised: 14 September 2021 / Accepted: 19 September 2021 / Published: 23 September 2021
(This article belongs to the Special Issue Novel Biomaterials for Wound Healing)

Round 1

Reviewer 1 Report

The manuscript by Qi et al. “Current biomaterial-based bone tissue engineering and translational medicine” is noteworthy. Few biomaterials (grafting materials) pieces of information are missing such as polyhydroxyalkanoates. This manuscript requires moderate revision.

 

Comments

  1. The introduction, highlights the major challenges of various BTE, and the objectives of this review with prospectives.
  2. Please verify the numbering of Table appearance in the manuscript. Table 2 (outcome), the quantitative information may be provided to highlight significance.
  3. Section 3, please add one paragraph on biomaterials as polyhydroxyalkanoates with their properties and suitability as materials for BTE i.e. highly biodegradable, anti-microbial properties, and biocompatibility.
  4. In the text, some actual quantitative pieces of information of citations may be provided instead of just qualitative information i.e. efficiency of BTE treatment, % of repair, and period.
  5. Section 5, the author may highlight as “BTE clinical application and challenges”. Provide changes and perspectives of advanced BTE strategies.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This is a timely and nice review on bone engineering. It has a very wide scope, which necessarily means that this review cannot dig too deeply into the specific topics, but I believe this work can still prove useful to a broad range of readers who desire to get an overview of the field. The review is well written and clear. I would probably dedicate a few more words on natural ceramic scaffold, e.g. natural apatite, because of the importance they have in the clinical practice. And I would do the same with collagen, a material that is commonly used in many clinical fields and that would probably deserve more space. The conclusion section is a bit too long to be a real conclusion: I would call that 'Dicussion' or maybe the authors can reframe it in a better way, and I would add a very brief 'Conclusion' at the end, just a passage or 2 with the take home message. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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